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MOG is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene Name: | myelin oligodendrocyte glycoprotein |
Family/Subfamily: | Immunoglobulin , not assigned-Immunoglobulin |
Synonyms: | MOG, NRCLP7, MOGIG2, MOG alpha-5, MOG Ig-AluB |
Target Sequences: | NM_002433 NP_002424.3 Q16653 |
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