MSH2

mutS homolog 2

Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

MSH2 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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Human MSH2 Protein (Recombinant GST) (Full Length) - LS-G29376

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

131.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MSH2 Protein (Recombinant GST, N-terminus) (aa835-934) - LS-G59277

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MSH2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65431

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

104.6 kDa

Price:

20 µg/$1,107

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Human MSH2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75548

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

104.6 kDa

Price:

20 µg/$150

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MSH2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123313

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

104.6 kDa

Price:

100 µg/$494

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Human MSH2 Protein (Recombinant His) (aa321-574) - LS-G141021

Source:

E. coli

Sequence Length:

253 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

27.94 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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