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MSLN / Mesothelin

mesothelin

This gene encodes a preproprotein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Alternative splicing results in multiple transcript variants. Mesothelin is a cell surface differentiation antigen found in mesothelial cells, mesotheliomas and ovarian cancers. Although the function of mesothelin is unknown, it may play a role in cellular adhesion. Three transcript variants have been described. Their protein products were initially named megakaryocyte potentiating factor (MPF), mesothelin, and the soluble member(s) of the mesothelin/MPF family. MPF is a cytokine with megakaryocyte potentiating activity. Mesothelin null mutant mice show a normal phenotype suggesting that mesothelin function is not essential for growth or reproduction in mice (Bera et al., 2000).

Gene Name: mesothelin
Synonyms: MSLN, CAK1 antigen, MPF, SMRP, Mesothelin, CAK1
Target Sequences: NM_013404 NP_037536.2 Q13421

Publications (5)

1
New monoclonal antibodies to mesothelin useful for immunohistochemistry, fluorescence-activated cell sorting, Western blotting, and ELISA. Onda M, Willingham M, Nagata S, Bera TK, Beers R, Ho M, Hassan R, Kreitman RJ, Pastan I. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 11:5840-6. [PubMed:16115924] Related Antibodies: LS-C154007.
2
A practical approach to pancreatic cancer immunotherapy using resected tumor lysate vaccines processed to express a-gal epitopes. Furukawa K, Tanemura M, Miyoshi E, Eguchi H, Nagano H, Matsunami K, Nagaoka S, Yamada D, Asaoka T, Noda T, Wada H, Kawamoto K, Goto K, Taniyama K, Mori M, Doki Y. PloS one. 2017 12:e0184901. (IHC-P; Human) [Full Text Article] [PubMed:29077749]
3
Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses. Watanabe K, Luo Y, Da T, Guedan S, Ruella M, Scholler J, Keith B, Young RM, Engels B, Sorsa S, Siurala M, Havunen R, Tähtinen S, Hemminki A, June CH. JCI insight. 2018 April;3:pii: 99573. (Mouse) [Full Text Article] [PubMed:29618658] [PMC:PMC5928866] Related Antibodies: LS-C179484.
4
Cell-Type-Specific Gene Regulatory Networks Underlying Murine Neonatal Heart Regeneration at Single-Cell Resolution. Zhaoning Wang, Miao Cui, Akansha M Shah, Wei Tan, Ning Liu, Rhonda Bassel-Duby, Eric N Olson. Cell reports. 2020 December;33:108472. [Full Text Article] [PubMed:33296652] [PMC:PMC7774872] Related Antibodies: LS-C407883.
5
The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion. Ugur Uslu , Lijun Sun , Sofia Castelli, Amanda V Finck, Charles-Antoine Assenmacher, Regina M Young, Zhijian J Chen, Carl H June. Nature communications. 2024 May;15:3933. [Full Text Article] [PubMed:38730243] Related Antibodies: LS-C179484.
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ELISA Kits (21)
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MSLN / Mesothelin (21)
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Mouse (3)
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MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
MSLN / Mesothelin ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
250 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$730
MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Saliva, Serum, Urine
1 Plate/$699
MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Microplate
Human
0.123 - 12 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.313 - 20 pmol/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MSLN / Mesothelin ELISA Kit
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Competitive EIA
96-Well Microplate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$764
MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$748
MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MSLN / Mesothelin ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
31 - 2000 pg/ml
Chemiluminescent
Cell Lysates, Plasma, Serum
1 Plate/$562
MSLN / Mesothelin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$582
MSLN / Mesothelin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
MSLN / Mesothelin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$968
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).