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NF-L / NEFL

neurofilament, light polypeptide

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.

Gene Name: neurofilament, light polypeptide
Synonyms: NEFL, 68 kDa neurofilament protein, CMT1F, CMT2E, NF68, NF-L, NFL, Neurofilament subunit NF-L, PPP1R110, Neurofilament light polypeptide, CMTDIG
Target Sequences: NM_006158 NP_006149.2 P07196

Publications (5)

1
Neuron-glia interactions underlie ALS-like axonal cytoskeletal pathology. King AE, Dickson TC, Blizzard CA, Woodhouse A, Foster SS, Chung RS, Vickers JC. Neurobiology of aging. 2011 32:459-69. (ICC, IHC; Mouse) [PubMed:19427060]
2
NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. Yokoyama K, Tezuka T, Kotani M, Nakazawa T, Hoshina N, Shimoda Y, Kakuta S, Sudo K, Watanabe K, Iwakura Y, Yamamoto T. The EMBO journal. 2011 30:4739-54. [PubMed:21946561] [PMC:PMC3243607]
3
Microbiome-Derived Lipopolysaccharide (LPS) Selectively Inhibits Neurofilament Light Chain (NF-L) Gene Expression in Human Neuronal-Glial (HNG) Cells in Primary Culture. Lukiw WJ, Cong L, Jaber V, Zhao Y. Frontiers in neuroscience. 2018 December;12:896. [Full Text Article] [PubMed:30568571] [PMC:PMC6289986]
4
Facility-based and home-based multidomain interventions including cognitive training, exercise, diet, vascular risk management, and motivation for older adults: a randomized controlled feasibility trial10<sup> Department of Neurology, Hanyang University College of Medicine, Seoul 04763, Republic of Korea12<sup> Lab for Neurodegenerative Dementia, Department of Anatomy, Ajou University School of Medicine, Suwon 16499, Republic of Korea14<sup> Department of Biomedical Systems Engineering, Korea Po. So Young Moon, Chang Hyung Hong, Jee Hyang Jeong, Yoo Kyoung Park, Hae Ri Na, Hong-Sun Song, Byeong C Kim, Kyung Won Park, Hee Kyung Park, Muncheong Choi, Sun Min Lee, Buong-O Chun, Seong-Ho Koh , Sun Ah Park , Hyun-Hee Park, Jeong-Hwa Jin, Eun-Hye Lee, Sue Min Kim , Song Mi Han , Jun Seok Kim, Jungsoon Ha, Seong Hye Choi. Aging. 2021 Jun;13:15898-15916. [Full Text Article] [PubMed:34148030] [PMC:PMC8266338]
5
Phase I Trial of Intra-arterial Administration of Autologous Bone Marrow-Derived Mesenchymal Stem Cells in Patients with Multiple System Atrophy. Seok Jong Chung , Tae Yong Lee, Yang Hyun Lee, KyoungWon Baik, Jin Ho Jung , Han Soo Yoo, Chang Jae Shim, Hyojin Eom, Ji-Yeon Hong, Dong Joon Kim, Young H Sohn, Phil Hyu Lee. Stem cells international. 2021 Oct;2021:9886877. [Full Text Article] [PubMed:34712335] [PMC:PMC8548132]
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Proteins (9)
Over-Expression Lysate (2)
Recombinant (7)
NF-L / NEFL (9)
No (9)
10His, N-terminus (1)
10His-SUMO, N-terminus + Myc, C-terminus (1)
6His, N-terminus (1)
GST (1)
His (2)
Myc-DDK (Flag) (3)
Human (6)
Mouse (2)
293T Cells (1)
E. coli (4)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Yeast (1)
Purified (3)
Low endotoxin level (1)
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Human NF-L / NEFL Protein (Recombinant His) (aa1-200) - LS-G141102
E. coli
542 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
59.73 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
NF-L / NEFL Protein
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Mouse NF-L / NEFL Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G23053
Yeast
6His, N-terminus
63.38 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
NF-L / NEFL Protein - Recombinant Neurofilament, Light Polypeptide By SDS-PAGE
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Mouse NF-L / NEFL Protein (Recombinant His) (aa139-234) - LS-G15428
E. coli
His
12.6 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
NF-L / NEFL Protein - Purified recombinant protein NEFL was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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Human NF-L / NEFL Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66416
HEK 293 Cells
Myc-DDK (Flag)
61.3 kDa
20 µg/$1,107
NF-L / NEFL Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Human NF-L / NEFL Protein (Recombinant 10His-SUMO, N-terminus + Myc, C-terminus) (aa2-543) - LS-G56420
E. coli
10His-SUMO, N-terminus + Myc, C-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
NF-L / NEFL Protein - 12.5% SDS-PAGE of human NEFL stained with Coomassie Blue
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Human NF-L / NEFL Protein (Recombinant GST) (Full Length) - LS-G29492
Wheat Germ Extract
GST
87.9 kDa
2 µg/$439
NF-L / NEFL Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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Human NF-L / NEFL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77646
293T Cells
Myc-DDK (Flag)
61.3 kDa
20 µg/$150
NF-L / NEFL Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
NF-L / NEFL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115492
HEK 293 Cells
Myc-DDK (Flag)
61.3 kDa
100 µg/$494
NF-L / NEFL Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Human NF-L / NEFL Protein (Recombinant 10His, N-terminus) (aa2-543) - LS-G56012
E. coli
10His, N-terminus
64.9 kDa
100 µg/$1,128; 20 µg/$721
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