NFKB1 / NF-Kappa-B

nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.

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Products

ELISA Kits (39)

Type

Cell-Based (1)

Cell-Based Phosphorylation (5)

Custom (2)

Development Kit (3)

DNA Binding (1)

DNA Binding Phosphorylation (2)

Sandwich (20)

Sandwich CLIA (5)

Target

NFKB1 / NF-Kappa-B (39)

Reactivity

Human (16)

Mouse (13)

Rat (11)

Chicken (3)

Dog (1)

Monkey (2)

Pig (1)

Porcine (1)

Product Group

DevKit DuoPlus (3)

Format

12 x 8-Well Microstrips (7)

96-Well Microplate (9)

96-Well Strip Plate (20)

Antibody Pair and Standard (3)

Publications

No (37)

Yes (2)

Sample Type

Adherent Cell Cultures (6)

Cell Culture Supernatants (3)

Cell Lysates (12)

Nuclear Lysates (3)

Plasma (15)

Serum (15)

Tissue Homogenates (13)

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Dog NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F18607

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Dog

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Rat NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F21577

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Human Phospho-NFKB1 / NF-Kappa-B (Ser337) (DNA-Binding Phosphorylation ELISA) ELISA Kit - LS-F891

Type:

DNA Binding Phosphorylation

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$735

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Mouse NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F12149

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F21089

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Rat NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F12148

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human NFKB1 / NF-Kappa-B (CLIA) ELISA Kit - LS-F29893

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Mouse/Human/Rat NFKB1 / NF-Kappa-B (DNA-Binding ELISA) ELISA Kit - LS-F893

Type:

DNA Binding

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$694

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Mouse/Human NFKB1 / NF-Kappa-B (Cell-Based ELISA) ELISA Kit - LS-F2185

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse/Human Phospho-NFKB1 / NF-Kappa-B (Ser337) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1070

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human Phospho-NFKB1 / NF-Kappa-B (Ser927) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1049

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Human NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F5032

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

Select

Chicken NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F5001

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$750

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Rat NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F5020

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$750

Select

Mouse NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F7768

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$705

Select

Mouse NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F35644

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F35645

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F35646

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human NFKB1 / NF-Kappa-B (CLIA) ELISA Kit - LS-F30367

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Mouse NFKB1 / NF-Kappa-B (CLIA) ELISA Kit - LS-F30881

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Chicken NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F44933

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Monkey NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F44934

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Porcine NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F44935

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

Monkey NFKB1 / NF-Kappa-B (Sandwich ELISA) ELISA Kit - LS-F46220

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$656

Select

DevKit DuoPlus Rat NFKB1 / NF-Kappa-B ELISA Development Kit - LS-F72167

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Rat

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,305; 1000 Wells/$1,952

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