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NGF

nerve growth factor (beta polypeptide)

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.

Gene Name: nerve growth factor (beta polypeptide)
Family/Subfamily: NGF Beta , not assigned-NGF Beta
Synonyms: NGF, Beta-nerve growth factor, ProNGF, Beta-NGF, HSAN5, NGFB
Target Sequences: NM_002506 NP_002497.2 P01138

Publications (4)

1
Isorhynchophylline exerts antidepressant-like effects in mice via modulating neuroinflammation and neurotrophins: involvement of the PI3K/Akt/GSK-3ß signaling pathway. Xian YF, Ip SP, Li HQ, Qu C, Su ZR, Chen JN, Lin ZX. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 September;33:10393-10408. [Full Text Article] [PubMed:31233346]
2
Shp2-mediated MAPK pathway regulates ?Np63 in epithelium to promote corneal innervation and homeostasis. Yuka Okada, Yujin Zhang, Lingling Zhang, Lung-Kun Yeh, Yen-Chiao Wang, Shizuya Saika, Chia-Yang Liu. Laboratory investigation; a journal of technical methods and pathology. 2020 Apr;100:630-642. [Full Text Article] [PubMed:31653968] [PMC:PMC7102931] Related Antibodies: LS-C171793.
3
Targeted screening of inflammatory mediators in spontaneous degenerative disc disease in dogs reveals an upregulation of the tumor necrosis superfamily. Thomas Bitterli, David Schmid, Ladina Ettinger, Olga Krupkova, Frances C Bach, Marianna A Tryfonidou, Björn P Meij, Antonio Pozzi, Frank Steffen, Karin Wuertz-Kozak, Lucas A Smolders. JOR spine. 2024 March;7:e1292. [Full Text Article] [PubMed:38222814] [PMC:PMC10782068] Related Antibodies: LS-C388946.
4
Memantine increases the dendritic complexity of hippocampal young neurons in the juvenile brain after cranial irradiation. Georgios Alkis Zisiadis, Androniki Alevyzaki, Elene Nicola, Carlos F D Rodrigues, Klas Blomgren, Ahmed M Osman. Frontiers in oncology. 2023 October;13:1202200. [Full Text Article] [PubMed:37860190]
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Products
Proteins (32)
Native (1)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (1)
Recombinant (29)
NGF (32)
No (32)
6His, N-terminus (3)
6His-SUMO, N-terminus (1)
GST, N-terminus (1)
His (1)
His, N-Terminal (5)
Myc-DDK (Flag) (1)
Human (17)
Mouse (8)
Pig (4)
Rat (3)
293F Cells (1)
CHO Cells (2)
E. coli (20)
HEK 293 Cells (3)
Human Cells (1)
Mammalian Cells (2)
Wheat Germ Extract (1)
Yeast (1)
Purified (8)
Supernatant (1)
Low endotoxin level (17)
Biologically active (6)
NGF Protein - Active Nerve Growth Factor (NGF) by WB
Select
E. coli
His, N-Terminal
30/33kDa
10 µg/$307; 50 µg/$602; 200 µg/$1,156; 100 µg/$962; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,201; 2 mg/$2,562
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
13.5 kDa
5 µg/$268; 20 µg/$352
Select
Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
13.5kD
10 µg/$233; 50 µg/$277; 500 µg/$725; 1 mg/$1,113
Select
None
13 kDa
1 mg/$1,274
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
13.4kD
10 µg/$248; 50 µg/$321; 500 µg/$1,262; 1 mg/$1,627
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
25kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
12.4kD
10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
13.5kD
10 µg/$262; 50 µg/$365; 500 µg/$1,585; 1 mg/$2,157
NGF Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
NGF Protein - Purified recombinant protein NGF was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
24.9 kDa
20 µg/$1,107
Select
HEK 293 Cells
His, N-Terminal
~13 kDa
100 µg/$298
Select
HEK 293 Cells
His, N-Terminal
~13 kDa
200 µl/$283
Select
CHO Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
13.5 kDa
20 µg/$343
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
~14 kDa
20 µg/$286; 1 mg/$2,041
Select
CHO Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
20 µg/$319
NGF Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
13.4 kDa
50 µg/$356; 10 µg/$259; 1 mg/$2,064; 500 µg/$1,538
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
13.4 kDa
20 µg/$269; 100 µg/$360
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
13.5 kDa
20 µg/$360; 100 µg/$728
Select
Mammalian Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
13.5 kDa
10 µg/$233; 50 µg/$277
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
12.4 kDa
10 µg/$248; 50 µg/$288
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
25 kDa
10 µg/$288; 50 µg/$436
NGF Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
13.5 kDa
50 µg/$298; 10 µg/$240; 1 mg/$1,368; 500 µg/$952
NGF Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
12.4 kDa
50 µg/$313; 10 µg/$259; 1 mg/$1,470; 500 µg/$1,025
NGF Protein - Recombinant Nerve Growth Factor (NGF) by SDS-PAGE
Select
E. coli
His, N-Terminal
33kDa
10 µg/$283; 50 µg/$452; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
Select
E. coli
None
Biologically active
13.5 kDa
100 µg/$352; 20 µg/$268
Viewing 1-25 of 32 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).