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NKX3-1
NK3 homeobox 1
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
| Gene Name: | NK3 homeobox 1 |
| Synonyms: | NKX3-1, BAPX2, NK homeobox, family 3, A, NK3 homeobox 1, NKX3, NKX3.1, Homeobox protein Nkx-3.1, NKX3A |
| Target Sequences: | NM_006167 NP_006158.2 Q99801 |
Publications (4)
1
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. Kim MJ, Cardiff RD, Desai N, Banach-Petrosky WA, Parsons R, Shen MM, Abate-Shen C. Proceedings of the National Academy of Sciences of the United States of America. 2002 99:2884-9.
[PubMed:11854455]
[PMC:PMC122442]
2
A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis. Gao H, Ouyang X, Banach-Petrosky W, Borowsky AD, Lin Y, Kim M, Lee H, Shih WJ, Cardiff RD, Shen MM, Abate-Shen C. Proceedings of the National Academy of Sciences of the United States of America. 2004 101:17204-9.
[PubMed:15569926]
[PMC:PMC535400]
3
Nkx3.1 functions as para-transcription factor to regulate gene expression and cell proliferation in non-cell autonomous manner. Zhou J, Qin L, Tien JC, Gao L, Chen X, Wang F, Hsieh JT, Xu J. The Journal of biological chemistry. 2012 287:17248-56. (WB; Human, Rat)
[PubMed:22465996]
[PMC:PMC3366845]
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(116)
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(1)
NKX3-1 Mouse anti-Human Monoclonal (N-Terminus) (3-9) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$485
NKX3-1 Mouse anti-Human Monoclonal (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
100 µl/$1,017
NKX3-1 Mouse anti-Human Monoclonal (4H4) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$440
NKX3-1 Rabbit anti-Human Polyclonal (aa118-145) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
NKX3-1 Mouse anti-Human Monoclonal (0361) Antibody
Mouse, Rat
IHC, WB
Unconjugated
0.1 ml/$386
NKX3-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NKX3-1 Mouse anti-Human Monoclonal (UMAB196) Antibody
Human
IF, IHC, PMA, WB
Unconjugated
100 µl/$493
NKX3-1 Rabbit anti-Human Monoclonal (EP356) Antibody
Human
IHC-Fr, IHC-P
Unconjugated
0.1 ml/$409; 0.5 ml/$615; 1 ml/$1,004
NKX3-1 Rabbit anti-Human Monoclonal (Ready-to-Use) (EP356) Antibody
Human
IHC-Fr, IHC-P
Unconjugated, Ready-to-Use
3 ml/$409; 7 ml/$509; 15 ml/$766
NKX3-1 Mouse anti-Human Monoclonal (Carrier-free) (UMAB196) Antibody
Human
IF, IHC, PMA, WB
Unconjugated, Carrier-free
100 µg/$539
NKX3-1 Mouse anti-Human Monoclonal (4H4) Antibody
Human
Flo, IHC, WB
Unconjugated
100 µl/$541
NKX3-1 Mouse anti-Human Monoclonal (OTI2D11) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
NKX3-1 Mouse anti-Human Monoclonal (Carrier-free) (OTI2D11) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NKX3-1 Mouse anti-Human Monoclonal (OTI2A5) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
NKX3-1 Mouse anti-Human Monoclonal (Carrier-free) (OTI2A5) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NKX3-1 Mouse anti-Human Monoclonal (OTI6E7) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
NKX3-1 Mouse anti-Human Monoclonal (Carrier-free) (OTI6E7) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NKX3-1 Mouse anti-Human Monoclonal (OTI9H7) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
NKX3-1 Mouse anti-Human Monoclonal (Carrier-free) (OTI9H7) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NKX3-1 Mouse anti-Human Monoclonal (OTI1C2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
NKX3-1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1C2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NKX3-1 Mouse anti-Human Monoclonal (UMAB195) Antibody
Human
IHC, PMA
Unconjugated
100 µl/$493
NKX3-1 Mouse anti-Human Monoclonal (Carrier-free) (OTI4B4) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NKX3-1 Mouse anti-Human Monoclonal (Carrier-free) (OTI4H6) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NKX3-1 Rabbit anti-Human Polyclonal (1-80 aa, N-terminal) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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