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Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
Gene Name: | NK3 homeobox 1 |
Synonyms: | NKX3-1, BAPX2, NK homeobox, family 3, A, NK3 homeobox 1, NKX3, NKX3.1, Homeobox protein Nkx-3.1, NKX3A |
Target Sequences: | NM_006167 NP_006158.2 Q99801 |
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