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NOS1 / nNOS

nitric oxide synthase 1 (neuronal)

NOS1 / nNOS belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.

Gene Name: nitric oxide synthase 1 (neuronal)
Synonyms: NOS1, BNOS, Constitutive NOS, IHPS1, NNOS, NC-NOS, Nitric oxide synthase, brain, N-NOS, Neuronal NOS, NOS, NOS type I, Nos, type i
Target Sequences: NM_000620 NP_000611.1 P29475

Publications (4)

1
Senescent Cells Impair Erectile Function through Induction of Endothelial Dysfunction and Nerve Injury in Mice. Nishimatsu H, Suzuki E, Saito Y, Niimi A, Nomiya A, Fukuhara H, Kume H, Homma Y. PloS one. 2015 10:e0124129. (WB; Rat) [Full Text Article] [PubMed:25894557] [PMC:PMC4404101]
2
Neuromedin B Restores Erectile Function by Protecting the Cavernous Body and the Nitrergic Nerves from Injury in a Diabetic Rat Model. Nishimatsu H, Suzuki E, Saito Y, Niimi A, Nomiya A, Yamada D, Homma Y. PloS one. 2015 10:e0133874. (ICC, WB; Human, Rat) [Full Text Article] [PubMed:26207818] [PMC:PMC4514746]
3
PPARa induced NOS1 phosphorylation via PI3K/Akt in guinea pig antral mucous cells: NO-enhancement in Ca(2+)-regulated exocytosis. Tanaka S, Hosogi S, Sawabe Y, Shimamoto C, Matsumura H, Inui T, Marunaka Y, Nakahari T. Biomedical research (Tokyo, Japan). 2016 37:167-78. (WB; Human) [Full Text Article] [PubMed:27356604] Related Antibodies: LS-B3272.
4
PPAR alpha autocrine regulation of Ca2+-regulated exocytosis in guinea pig antral mucous cells: NO and cGMP accumulation. Tanaka S, Sugiyama N, Takahashi Y, Mantoku D, Sawabe Y, Kuwabara H, Nakano T, Shimamoto C, Matsumura H, Marunaka Y, Nakahari T. American journal of physiology. Gastrointestinal and liver physiology. Dec;307:G1169-79. [Full Text Article] [PubMed:25342048] Related Antibodies: LS-B3272.
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Proteins (12)
Over-Expression Lysate (2)
Recombinant (10)
NOS1 / nNOS (12)
No (12)
6His, N-terminus (1)
GST, N-terminus (1)
His (5)
His, N-Terminal (1)
His, N-terminus (1)
Myc-DDK (Flag) (3)
Human (4)
Mouse (4)
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293T Cells (1)
E. coli (8)
HEK 293 Cells (2)
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NOS1 / nNOS Protein - Recombinant Nitric Oxide Synthase 1, Neuronal By SDS-PAGE
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E. coli
6His, N-terminus
15.2 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
NOS1 / nNOS Protein - Recombinant Nitric Oxide Synthase 1, Neuronal By SDS-PAGE
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E. coli
His, N-terminus
21.9 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
NOS1 / nNOS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
160.8 kDa
20 µg/$215
NOS1 / nNOS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
160.8 kDa
100 µg/$710
NOS1 / nNOS Protein - Recombinant Nitric Oxide Synthase 1, Neuronal By SDS-PAGE
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E. coli
His, N-Terminal
16.8 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
NOS1 / nNOS Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
NOS1 / nNOS Protein - Purified recombinant protein NOS1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
160.8 kDa
20 µg/$1,107
NOS1 / nNOS Protein - Recombinant Nitric Oxide Synthase 1, Neuronal By SDS-PAGE
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E. coli
His
24.2 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
NOS1 / nNOS Protein - Recombinant Nitric Oxide Synthase 1, Neuronal By SDS-PAGE
Select
E. coli
His
16.1 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
NOS1 / nNOS Protein - Recombinant Nitric Oxide Synthase 1, Neuronal By SDS-PAGE
Select
E. coli
His
18.5 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
NOS1 / nNOS Protein - Recombinant Nitric Oxide Synthase 1, Neuronal By SDS-PAGE
Select
E. coli
His
20.5 kDa
10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257
NOS1 / nNOS Protein - Recombinant Nitric Oxide Synthase 1, Neuronal By SDS-PAGE
Select
E. coli
His
18.3 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).