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NRG1 / Heregulin / Neuregulin

neuregulin 1

Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells.

Gene Name: neuregulin 1
Synonyms: NRG1, ARIA, GGF, GGF2, Glial growth factor, Heregulin, HRGA, MSTP131, NDF, Neu differentiation factor, Neuregulin 1 type IV beta 3, Neuregulin 1 type IV beta 1a, HRG1, NRG-1, SMDF, Neuregulin 1, Pro-NRG1, HGL, MST131
Target Sequences: NM_013964 NP_039258.1 Q02297

Publications (1)

1
Cell Lineage-Based Stratification for Glioblastoma. Zilai Wang, Daochun Sun, Yu-Jung Chen, Xuanhua Xie, Yufeng Shi, Viviane Tabar, Cameron W Brennan, Tejus A Bale, Chenura D Jayewickreme, Dan R Laks, Sheila Alcantara Llaguno, Luis F Parada. Cancer cell. 2020 Sep;38:366-379.e8. [Full Text Article] [PubMed:32649888] [PMC:PMC7494533]

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Proteins (35)
Over-Expression Lysate (14)
Recombinant (21)
NRG1 / Heregulin / Neuregulin (35)
Animal-free (1)
No (34)
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6His, N-terminus (1)
GST (1)
His (4)
His-GST, N-terminus (1)
Myc-DDK (Flag) (14)
Human (24)
Mouse (1)
Rat (3)
293T Cells (7)
E. coli (20)
HEK 293 Cells (7)
Wheat Germ Extract (1)
Purified (8)
Low endotoxin level (12)
Biologically active (11)
Animal-free (1)
NRG1 / Heregulin / Neuregulin Protein - Recombinant Neuregulin 1 By SDS-PAGE
Select
E. coli
His-GST, N-terminus
45.3 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
29kD
10 µg/$248; 50 µg/$288; 500 µg/$785; 1 mg/$1,203
NRG1 / Heregulin / Neuregulin Protein
Select
E. coli
None
Biologically active
7.4 kDa
10 µg/$282; 100 µg/$503; 500 µg/$1,058
NRG1 / Heregulin / Neuregulin Protein - Recombinant Neuregulin 1 By SDS-PAGE
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E. coli
His
18.9 kDa
10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934
NRG1 / Heregulin / Neuregulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
67 kDa
20 µg/$150
NRG1 / Heregulin / Neuregulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
65.3 kDa
20 µg/$150
NRG1 / Heregulin / Neuregulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
34.2 kDa
20 µg/$150
NRG1 / Heregulin / Neuregulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
71 kDa
20 µg/$215
NRG1 / Heregulin / Neuregulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
26 kDa
20 µg/$150
NRG1 / Heregulin / Neuregulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
26 kDa
20 µg/$150
NRG1 / Heregulin / Neuregulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
70.2 kDa
20 µg/$215
NRG1 / Heregulin / Neuregulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
71 kDa
100 µg/$710
NRG1 / Heregulin / Neuregulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
26 kDa
100 µg/$494
NRG1 / Heregulin / Neuregulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
26 kDa
100 µg/$494
NRG1 / Heregulin / Neuregulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
70.2 kDa
100 µg/$710
NRG1 / Heregulin / Neuregulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
34.2 kDa
100 µg/$494
NRG1 / Heregulin / Neuregulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
65.3 kDa
100 µg/$494
NRG1 / Heregulin / Neuregulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
67 kDa
100 µg/$494
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E. coli
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
7.0 kDa
50 µg/$364
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
7.5 kDa
10 µg/$268; 50 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
10 µg/$281; 50 µg/$369
NRG1 / Heregulin / Neuregulin Protein - 12.5% SDS-PAGE of human NRG1 stained with Coomassie Blue
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Wheat Germ Extract
GST
52.5 kDa
2 µg/$439
NRG1 / Heregulin / Neuregulin Protein
Select
E. coli
None
Biologically active
7.0 kDa
10 µg/$282; 100 µg/$503; 500 µg/$1,058
NRG1 / Heregulin / Neuregulin Protein
Select
E. coli
None
Biologically active
7.5 kDa
10 µg/$282; 100 µg/$503; 500 µg/$1,058
NRG1 / Heregulin / Neuregulin Protein - Recombinant Neuregulin 1 By SDS-PAGE
Select
E. coli
His
26.3 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
Viewing 1-25 of 35 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).