PAX5

paired box 5

PAX5 is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. Paired box transcription factors are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

PAX5 (6)

Publications

No (6)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human PAX5 Protein (Recombinant 6His, N-terminus) (Asp2-His391) - LS-G26480

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

42 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human PAX5 Protein (Recombinant GST) (Full Length) - LS-G29627

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

68.5 kDa

Price:

2 µg/$439

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Human PAX5 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66517

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

20 µg/$1,107

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Human PAX5 Protein (Recombinant GST, N-terminus) (aa192-301) - LS-G59509

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PAX5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77899

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

20 µg/$150

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PAX5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112503

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42 kDa

Price:

100 µg/$494

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