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PDPN / Podoplanin
podoplanin
May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.
| Gene Name: | podoplanin |
| Synonyms: | PDPN, AGGRUS, HT1alpha-1, Glycoprotein 36, Glycoprotein, 36-KD, gp36, gp38, OTS8, PA2.26, PA2.26 antigen, Podoplanin, T1A, gp40, HT1A-1, HT1alpha-2, p38, T1-alpha, T1A-2 |
| Target Sequences: | NM_006474 NP_006465.3 Q86YL7 |
Publications (14)
1
Characterization of an antigenic determinant preferentially expressed by type I epithelial cells in the murine thymus. Farr A, Nelson A, Hosier S. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1992 40:651-64.
[PubMed:1374092]
2
Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues. Farr AG, Berry ML, Kim A, Nelson AJ, Welch MP, Aruffo A. The Journal of experimental medicine. 1992 176:1477-82.
[PubMed:1402691]
[PMC:PMC2119410]
3
T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. Schacht V, Ramirez MI, Hong YK, Hirakawa S, Feng D, Harvey N, Williams M, Dvorak AM, Dvorak HF, Oliver G, Detmar M. The EMBO journal. 2003 22:3546-56.
[PubMed:12853470]
[PMC:PMC165612]
☰ Filters
Products
Proteins
(18)
Type
Over-Expression Lysate
(4)
Recombinant
(14)
Target
PDPN / Podoplanin
(18)
Publications
No
(18)
Tag
6His, C-terminus
(2)
Fc, C-terminus
(5)
GST
(1)
His
(2)
His-Fc
(2)
His-GST
(1)
His-T7
(1)
Myc-DDK (Flag)
(4)
Species
Human
(10)
Mouse
(5)
Rat
(1)
Source
293T Cells
(2)
Baculovirus
(1)
E. coli
(3)
HEK 293 Cells
(3)
Human Cells
(4)
Mammalian Cells
(4)
Wheat Germ Extract
(1)
Purification
Purified
(5)
Low Endotoxin Level
Low endotoxin level
(10)
E. coli
His-GST
42.2 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
12.16kD
10 µg/$262; 50 µg/$365; 500 µg/$1,585; 1 mg/$2,157
E. coli
His-T7
26.2 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
Wheat Germ Extract
GST
51.3 kDa
10 µg/$479; 25 µg/$670
Baculovirus
His
Less than 1.0 EU/µg protein (determined by LAL method).
13 kDa
100 µg/$721
Human Cells
His-Fc
Less than 1.0 EU/µg protein (determined by LAL method).
40.6 kDa
100 µg/$721
HEK 293 Cells
Myc-DDK (Flag)
24.7 kDa
100 µg/$494
293T Cells
Myc-DDK (Flag)
24.7 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
24.5 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
24.5 kDa
100 µg/$494
Mammalian Cells
Fc, C-terminus
Less than 0.1 ng/mL (Less than 1 EU/µg) (determined by LAL method).
10 µg/$269; 50 µg/$372; 500 µg/$1,245; 1 mg/$1,627
HEK 293 Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
38.6 kDa
200 µg/$1,070
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
12.1 kDa
10 µg/$281; 50 µg/$389
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
12.2 kDa
10 µg/$262; 50 µg/$361
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
38.6 kDa
10 µg/$269; 50 µg/$368
Human Cells
His-Fc
Less than 1.0 EU/µg protein (determined by LAL method).
38.6 kDa
100 µg/$721
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
12.1kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
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