PIM1 / Pim-1

pim-1 oncogene

Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis.

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Products

ELISA Kits (10)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Custom (3)

Sandwich (4)

Sandwich CLIA (1)

Target

PIM1 / Pim-1 (10)

Reactivity

Human (7)

Mouse (3)

Rat (3)

Format

96-Well Microplate (2)

96-Well Strip Plate (8)

Publications

No (10)

Sample Type

Adherent Cell Cultures (2)

Cell Culture Supernatants (2)

Plasma (5)

Serum (5)

Tissue Homogenates (4)

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Human PIM1 / Pim-1 (Sandwich ELISA) ELISA Kit - LS-F7734

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$730

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Rat PIM1 / Pim-1 (Sandwich ELISA) ELISA Kit - LS-F19006

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Mouse/Human/Rat PIM1 / Pim-1 (Cell-Based ELISA) ELISA Kit - LS-F2245

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse/Human/Rat Phospho-PIM1 / Pim-1 (Tyr309) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1272

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse PIM1 / Pim-1 (Custom ELISA) ELISA Kit - LS-F19003

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Bovine PIM1 / Pim-1 (Custom ELISA) ELISA Kit - LS-F19005

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Human PIM1 / Pim-1 (Custom ELISA) ELISA Kit - LS-F19004

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Human PIM1 / Pim-1 (Sandwich ELISA) ELISA Kit - LS-F52418

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$897

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Human PIM1 / Pim-1 (CLIA) ELISA Kit - LS-F25868

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.069 - 50 ng/ml

Detection:

Chemiluminescent

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$851

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Human PIM1 / Pim-1 (Sandwich ELISA) ELISA Kit - LS-F36113

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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