PMS2

postmeiotic segregation increased 2

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages.

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Products

Antibodies (36)

Type

Primary (36)

Target

PMS2 (36)

Reactivity

Human (35)

Mouse (5)

Rat (4)

Bovine (3)

Chimpanzee (4)

Gibbon (3)

Guinea pig (3)

Hamster (1)

Monkey (3)

Pig (3)

Application

IHC (15)

IHC-P (4)

WB (28)

Flo (1)

ELISA (12)

ICC (1)

IF (10)

IP (3)

Peptide-ELISA (4)

Host

rabbit (24)

mouse (12)

Product Group

IHCPlus (2)

Isotype

IgG (17)

IgG1 (6)

IgG1,k (1)

IgG2a,k (1)

IgG2b (4)

Clonality

monoclonal mc (13)

polyclonal pc (22)

recombinant monoclonal rmc (1)

Clone

1204 (1)

163C1251 (1)

1E9D11 (1)

4G4 (1)

A164 (1)

G412.1 (1)

OTI2G5 (2)

OTI4B7 (2)

Format

Biotin Conjugated (1)

Carrier-free (2)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (33)

Epitope

aa611-660 (4)

100-180 aa, C-terminal (1)

430-510 aa, Internal (1)

Asp483 (1)

aa1-133 (1)

aa125-174 (1)

aa434-483 (1)

aa461-510 (1)

aa600-650 (1)

Publications

No (36)

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IHC-plus™ PMS2 Antibody (aa600-650, clone 163C1251) LS-B1980

(4.0) Rating

Antibody:

PMS2 Mouse anti-Human Monoclonal (aa600-650) (163C1251) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$440

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PMS2 Antibody (aa1-133, clone 1204) LS-C59521

Antibody:

PMS2 Mouse anti-Human Monoclonal (aa1-133) (1204) Antibody

Reactivity:

Mouse, Rat, Hamster, Chimpanzee, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$574

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PMS2 Antibody (clone OTI4B7) LS-C338148

Antibody:

PMS2 Mouse anti-Human Monoclonal (OTI4B7) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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PMS2 Antibody (clone OTI4B7, Carrier-free) LS-C788261

Antibody:

PMS2 Mouse anti-Human Monoclonal (Carrier-free) (OTI4B7) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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IHC-plus™ PMS2 Antibody (aa125-174) LS-B5688

(4.0) Rating

Antibody:

PMS2 Rabbit anti-Human Polyclonal (aa125-174) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$460

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PMS2 Antibody LS-C346151

Antibody:

PMS2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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PMS2 Antibody LS-C835049

Antibody:

PMS2 Rabbit anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

100 µl/$373; 200 µl/$493

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PMS2 Antibody (430-510 aa, Internal) LS-C385580

Antibody:

PMS2 Rabbit anti-Human Polyclonal (430-510 aa, Internal) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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PMS2 Antibody LS-C826656

Antibody:

PMS2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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PMS2 Antibody (clone OTI2G5) LS-C338149

Antibody:

PMS2 Mouse anti-Human Monoclonal (OTI2G5) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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PMS2 Antibody (clone OTI2G5, Carrier-free) LS-C788257

Antibody:

PMS2 Mouse anti-Human Monoclonal (Carrier-free) (OTI2G5) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

PMS2 Antibody LS-C403442

Antibody:

PMS2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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PMS2 Antibody (Asp483) LS-C177136

Antibody:

PMS2 Rabbit anti-Human Polyclonal (Asp483) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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PMS2 Antibody LS-C667972

Antibody:

PMS2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

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PMS2 Antibody LS-C748716

Antibody:

PMS2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IP, WB

Format:

Unconjugated

Price:

20 µl/$287; 100 µl/$431

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PMS2 Antibody LS-C772799

Antibody:

PMS2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IP, WB

Format:

Unconjugated

Price:

60 µl/$343; 120 µl/$427; 200 µl/$559

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PMS2 Antibody (clone 1E9D11) LS-C669332

Antibody:

PMS2 Mouse anti-Human Monoclonal (1E9D11) Antibody

Reactivity:

Human

Applications:

ELISA, Flo

Format:

Unconjugated

Price:

100 µl/$459

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PMS2 Antibody LS-C804055

Antibody:

PMS2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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PMS2 Antibody (100-180 aa, C-terminal) LS-C385578

Antibody:

PMS2 Rabbit anti-Human Polyclonal (100-180 aa, C-terminal) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

PMS2 Antibody LS-C405993

Antibody:

PMS2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

PMS2 Antibody LS-C752705

Antibody:

PMS2 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$361

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PMS2 Antibody LS-C752707

Antibody:

PMS2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$331

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PMS2 Antibody LS-C662504

Antibody:

PMS2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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PMS2 Antibody LS-C823633

Antibody:

PMS2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

PMS2 Antibody (clone G412.1) LS-C783598

Antibody:

PMS2 Mouse anti-Human Monoclonal (G412.1) Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

100 µl/$421

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