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POMC / Proopiomelanocortin

proopiomelanocortin

POMC / Proopiomelanocortin is a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

Gene Name: proopiomelanocortin
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: POMC, Alpha-MSH, ACTH, Adrenocorticotropin, Adrenocorticotropic hormone, Beta-LPH, CLIP, Gamma-MSH, Lipotropin gamma, LPH, Melanotropin alpha, Met-enkephalin, Melanotropin beta, NPP, Pro-ACTH-endorphin, Lipotropin beta, Melanotropin gamma, MSH, Proopiomelanocortin, Beta-endorphin, Beta-MSH, Gamma-LPH, POC, Pro-opiomelanocortin
Target Sequences: NM_000939 NP_000930.1 P01189

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Products
ELISA Kits (35)
Competitive EIA (15)
Custom (4)
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Sandwich CLIA (2)
POMC / Proopiomelanocortin (35)
Human (8)
Mouse (8)
Rat (6)
Chicken (2)
Guinea pig (2)
Monkey (2)
Pig (1)
Porcine (2)
Rabbit (2)
Sheep (1)
12 x 8-Well Microstrips (2)
96-Well Microplate (3)
96-Well Strip Plate (30)
No (35)
Cell Culture Supernatants (2)
Cell Lysates (2)
Plasma (19)
Serum (20)
Tissue Homogenates (2)
POMC / Proopiomelanocortin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
123.5 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$750
POMC / Proopiomelanocortin ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.39 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
POMC / Proopiomelanocortin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
POMC / Proopiomelanocortin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
POMC / Proopiomelanocortin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Serum
1 Plate/$579
POMC / Proopiomelanocortin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
POMC / Proopiomelanocortin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
POMC / Proopiomelanocortin ELISA Kit
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Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
POMC / Proopiomelanocortin ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
POMC / Proopiomelanocortin ELISA Kit
Select
Custom
96-Well Strip Plate
Pig
Colorimetric - 450nm (TMB)
1 Plate/$669
POMC / Proopiomelanocortin ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
POMC / Proopiomelanocortin ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
POMC / Proopiomelanocortin ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
POMC / Proopiomelanocortin ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
5 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
POMC / Proopiomelanocortin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
POMC / Proopiomelanocortin ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Rat
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
POMC / Proopiomelanocortin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
POMC / Proopiomelanocortin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
123.46 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$798
POMC / Proopiomelanocortin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
123.46 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
POMC / Proopiomelanocortin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
25 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
POMC / Proopiomelanocortin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Mouse
78.125 - 5000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
POMC / Proopiomelanocortin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.391 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$579
POMC / Proopiomelanocortin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
POMC / Proopiomelanocortin ELISA Kit
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Sandwich
96-Well Microplate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$614
POMC / Proopiomelanocortin ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).