POMC / Proopiomelanocortin

proopiomelanocortin

POMC / Proopiomelanocortin is a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

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Products

Proteins (10)

Type

Over-Expression Lysate (3)

Recombinant (6)

Synthetic Peptide (1)

Target

POMC / Proopiomelanocortin (10)

Publications

No (10)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (6)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Synthetic (1)

Wheat Germ Extract (2)

Purification

Purified (4)

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Human POMC / Proopiomelanocortin Protein (Recombinant His) - LS-G1310

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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Human POMC / Proopiomelanocortin Protein (Over-Expression Lysate 6His, N-terminus) (Pro2-Glu267) - LS-G26682

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

29 kDa

Price:

100 µg/$298

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Mouse POMC / Proopiomelanocortin Protein (Recombinant His-T7) (aa27-235) - LS-G13636

Source:

E. coli

Tag:

His-T7

Molecular Weight:

25.0 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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POMC / Proopiomelanocortin Protein (Synthetic Peptide) - LS-G37549

Source:

Synthetic

Tag:

None

Molecular Weight:

1665 Da

Price:

0.5 mg/$293

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Human POMC / Proopiomelanocortin Protein (Recombinant GST) (Full Length) - LS-G29815

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

55.8 kDa

Price:

2 µg/$439

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Human POMC / Proopiomelanocortin Protein (Recombinant GST, N-terminus) (aa205-267) - LS-G59669

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human POMC / Proopiomelanocortin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75319

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.42 kDa

Price:

20 µg/$150

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POMC / Proopiomelanocortin Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120677

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

29.42 kDa

Price:

100 µg/$494

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Human POMC / Proopiomelanocortin Protein (Recombinant His, N-Terminal) (Glu23-Glu267) - LS-G24271

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

30.9 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Rat POMC / Proopiomelanocortin Protein (Recombinant His-GST) (aa27-235) - LS-G13635

Source:

E. coli

Tag:

His-GST

Molecular Weight:

56.1 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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