PPARG / PPAR Gamma

peroxisome proliferator-activated receptor gamma

Peroxisome proliferator-activated receptor gamma (PPAR gamma), a NR1 Thyroid Hormone-Like Receptor, is a transcription factor that regulates genes involved in lipid metabolism and adipocyte differentiation and has been shown to affect placental differentiation and cell proliferation and differentiation pathways in various diseases such as Type II diabetes and atherosclerosis. Recently, PPAR gamma has been suggested to affect inflammatory digestive diseases (Dubuquoy et al. 2002). PPAR gamma binds target DNA as a heterodimer (with retinoid X receptors) and has several coactivators, including steroid receptor coactivator-1 (SRC-1) and PPAR-binding protein (PBP). Two isoforms of PPAR gamma protein have been identified: PPAR gamma2 contains 30 additional amino acids at the N terminus compared to PPAR gamma1. PPAR gamma2 is expressed mainly in adipose tissue, whereas PPAR gamma1 is expressed widely. Mutations in PPAR gamma2 have been implicated in the development of obesity and Type II diabetes. PPAR gamma is the molecular target of thiazolidinediones (TZDs), drugs used widely for treatment of Type II diabetes, and is believed to mediate the apoptotic effects of this class of drugs in a variety of cell types, including B and T lymphocytes. Altered expression of PPAR gamma and cyclooxygenase-2 (COX-2) and the subsequent modulation in the tissue levels of PGE(2) and 15-d-PGJ(2) may influence the development of human breast cancer and its progression to metastasis.

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Products

Antibodies (139)

Type

Primary (139)

Target

PPARG / PPAR Gamma (139)

Reactivity

Human (108)

Mouse (62)

Rat (57)

Bat (4)

Boar (1)

Bovine (12)

Chicken (4)

Chimpanzee (9)

Cow (8)

Dog (15)

Duck (1)

Gibbon (12)

Goat (3)

Guinea pig (7)

Hamster (8)

Horse (7)

Macaque (2)

Mink (1)

Monkey (14)

Orangutan (7)

Pig (22)

Rabbit (13)

Squirrel (1)

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Application

IHC (25)

IHC-P (12)

WB (133)

Flo (7)

ELISA (28)

GS (1)

ICC (2)

IF (9)

IP (7)

Peptide-ELISA (4)

Host

rabbit (118)

mouse (18)

guinea pig (3)

Product Group

IHCPlus (7)

Isotype

IgG (50)

IgG1 (6)

IgG2a (1)

IgG2b,k (8)

Clonality

monoclonal mc (18)

polyclonal pc (121)

Clone

3A4A9 (1)

3A4A9, 1E6A1 (1)

8D1H8F4 (2)

Format

APC (6)

APC Conjugated (7)

Azide-free (1)

Biotin Conjugated (14)

Cy3 Conjugated (6)

Cy7 Conjugated (6)

FITC Conjugated (14)

HRP Conjugated (12)

Magnetic beads Conjugated (1)

PE Conjugated (7)

Sepharose Conjugated (1)

Unconjugated (71)

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Epitope

N-Terminus (13)

aa149-273 (11)

aa157-274 (8)

aa311-493 (8)

aa311-500 (8)

aa349-488 (8)

aa1-30 (7)

C-Terminus (6)

pSer112 (6)

aa57-106 (4)

aa280-475 (3)

50-130 aa (2)

Amino Acid: 170-270 (1)

Ile106 (1)

Internal (1)

aa1-16 (1)

aa100-150 (1)

aa170-270 (1)

aa2-35 (1)

aa20-120 (1)

aa255-268 (1)

aa50-100 (1)

aa76-93 (1)

aa78-127 (1)

aa82-101 (1)

aa95-124 (1)

p112 (1)

pSer273 (1)

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Publications

No (135)

Yes (4)

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IHC-plus™ PPARG / PPAR Gamma Antibody (clone 8D1H8F4) LS-B7391

(5.0) Rating

(1) Publication(s)

Antibody:

PPARG / PPAR Gamma Mouse anti-Human Monoclonal (8D1H8F4) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ PPARG / PPAR Gamma Antibody LS-B651

(5.0) Rating

(2) Publication(s)

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal Antibody

Reactivity:

Duck, Squirrel, Boar, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Mink, Macaque, Orangutan, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$515

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IHC-plus™ PPARG / PPAR Gamma Antibody (aa1-16) LS-B2818

(4.0) Rating

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (aa1-16) Antibody

Reactivity:

Human, Monkey

Applications:

GS, ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$535

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PPARG / PPAR Gamma Antibody (phospho-Ser273) LS-C209422

(4.0) Rating

(1) Publication(s)

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (pSer273) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$567

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IHC-plus™ PPARG / PPAR Gamma Antibody (aa170-270, clone 3A4A9) LS-B3892

(4.0) Rating

Antibody:

PPARG / PPAR Gamma Mouse anti-Human Monoclonal (aa170-270) (3A4A9) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$440

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PPARG / PPAR Gamma Antibody (C-Terminus) LS-C178333

(4.1) Rating

(2) Publication(s)

Antibody:

PPARG / PPAR Gamma Mouse anti-Human Monoclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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IHC-plus™ PPARG / PPAR Gamma Antibody (aa82-101) LS-B1606

(4.0) Rating

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (aa82-101) Antibody

Reactivity:

Dog, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$460

Select

IHC-plus™ PPARG / PPAR Gamma Antibody LS-B130

(4.0) Rating

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human, Macaque

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$515

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PPARG / PPAR Gamma Antibody (clone 8D1H8F4) LS-C47203

Antibody:

PPARG / PPAR Gamma Mouse anti-Human Monoclonal (8D1H8F4) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

0.1 ml/$419

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PPARG / PPAR Gamma Antibody (Internal) LS-C368478

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Rabbit, Mouse, Dog, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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PPARG / PPAR Gamma Antibody (phospho-Ser112) LS-C416660

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (pSer112) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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PPARG / PPAR Gamma Antibody (aa1-30, FITC) LS-C266793

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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PPARG / PPAR Gamma Antibody (aa1-30, PE) LS-C266794

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (aa1-30) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

PE Conjugated

Price:

200 µl/$952

• FITC
• PE

• FITC
• PE

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PPARG / PPAR Gamma Antibody (aa1-30) LS-C163891

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (aa1-30) Antibody

Reactivity:

Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

400 µl/$393

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PPARG / PPAR Gamma Antibody (C-Terminus) LS-C169542

Antibody:

PPARG / PPAR Gamma Rabbit anti-Rat Polyclonal (C-Terminus) Antibody

Reactivity:

Rat

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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PPARG / PPAR Gamma Antibody (aa95-124) LS-C801594

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (aa95-124) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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PPARG / PPAR Gamma Antibody (50-130 aa) LS-C380917

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (50-130 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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PPARG / PPAR Gamma Antibody LS-C38304

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

100 µl/$688

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PPARG / PPAR Gamma Antibody (aa157-274, Biotin) LS-C299243

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (aa157-274) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217

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PPARG / PPAR Gamma Antibody LS-C813089

Antibody:

PPARG / PPAR Gamma Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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PPARG / PPAR Gamma Antibody (aa149-273, APC, Cy7) LS-C731662

Antibody:

PPARG / PPAR Gamma Rabbit anti-Mouse Polyclonal (aa149-273) (APC, Cy7) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$483; 200 µl/$599; 500 µl/$1,089; 1 ml/$1,297; 2 ml/$1,815; 5 ml/$3,403

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PPARG / PPAR Gamma Antibody LS-C191902

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

Select

PPARG / PPAR Gamma Antibody (phospho-Ser112) LS-C177982

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (pSer112) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$328; 100 µl/$419

Select

PPARG / PPAR Gamma Antibody (N-Terminus) LS-C122330

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$798

Select

PPARG / PPAR Gamma Antibody (aa78-127) LS-C117700

Antibody:

PPARG / PPAR Gamma Rabbit anti-Human Polyclonal (aa78-127) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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