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PR / Progesterone Receptor

progesterone receptor

The progesterone receptor, a NR3 Steroid Receptor, is induced in granulosa cells of preovulatory follicles in response to surges in luteinizing hormone. It is essential for ovulation and egg implantation. A decrease in expression of endometrial progesterone receptor results in infertility in women. This receptor mediates the progesterone-induced transcription of proteases including ADAMTS1 and cathepsin L. In breast cancer, progesterone receptors are associated with hormone dependence and prolonged survival. At least two alternatively spliced isoforms have been identified in human: hPR-A (94 kD) is 164 aa shorter than hPR-B (114 kD). In most cell contexts, hPR-B functions as a transcriptional activator of progesterone-responsive genes, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors. hPR-A and hPR-B have been shown to regulate different sets of genes in human breast cancer cells. Some of these PR-regulated genes are implicated in breast cancer.

Gene Name: progesterone receptor
Family/Subfamily: NHR , NR3 Steroid receptor
Synonyms: PGR, NR3C3, PR, Progesterone receptor
Target Sequences: NM_000926 AAS00096.1 P06401

Publications (6)

1
Multiplexed assessment of the Southwest Oncology Group-directed Intergroup Breast Cancer Trial S9313 by AQUA shows that both high and low levels of HER2 are associated with poor outcome. Harigopal M, Barlow WE, Tedeschi G, Porter PL, Yeh IT, Haskell C, Livingston R, Hortobagyi GN, Sledge G, Shapiro C, Ingle JN, Rimm DL, Hayes DF. The American journal of pathology. 2010 176:1639-47. (IHC) [PubMed:20150438] [PMC:PMC2843456]
2
Evaluation of uterine receptivity after gonadotropin releasing hormone agonist administration as an oocyte maturation trigger: a rodent model. Ezoe K, Murata N, Yabuuchi A, Kobayashi T, Kato K. Scientific reports. 2019 August;9:12519. [Full Text Article] [PubMed:31467307] [PMC:PMC6715633]
3
Immunohistochemistry in Investigative and Toxicologic Pathology. Kyathanahalli S Janardhan, Heather Jensen, Natasha P Clayton, Ronald A Herbert. Toxicologic pathology. 2018 July;46:488-510. [Full Text Article] [PubMed:29966501] [PMC:PMC6033701]
4
Differentiation Patterns of Uterine Carcinomas and Precursor Lesions Induced by Neonatal Estrogen Exposure in Mice. Alisa A Suen, Wendy N Jefferson, Carmen J Williams, Charles E Wood. Toxicologic pathology. 2018 July;46:574-596. [Full Text Article] [PubMed:29895210] [PMC:PMC6027618]
5
Uterine Paramesonephric Cysts in Sprague-Dawley Rats from National Toxicology Program Studies. Daven N Jackson-Humbles, John Curtis Seely, Ronald A Herbert, David E Malarkey, Barry S McIntyre, Paul M Foster, Darlene Dixon. Toxicologic pathology. 2018 Jun;46:421-430. [Full Text Article] [PubMed:29706125] [PMC:PMC5999558]
6
Establishment of two basal-like breast cancer cell lines with extremely low tumorigenicity from Taiwanese premenopausal women. Wen-Ling Kuo, Shir-Hwa Ueng, Chun-Hsing Wu, Li-Yu Lee, Yun-Shien Lee, Ming-Chin Yu, Shin-Cheh Chen, Chi-Chang Yu, Chi-Neu Tsai. Human cell. 2018 Apr;31:154-166. [Full Text Article] [PubMed:29484537] [PMC:PMC5852199] Related Antibodies: LS-C133381.
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PR / Progesterone Receptor Antibody - Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human breast cancer. [antibody concentration 3 ug/ml]
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PR / Progesterone Receptor Mouse anti-Human Monoclonal (4E9) Antibody
Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$423
PR / Progesterone Receptor Antibody - Anti-PGR / Progesterone Receptor antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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PR / Progesterone Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µl/$485
PR / Progesterone Receptor ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PR / Progesterone Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
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PR / Progesterone Receptor Rabbit anti-Human Monoclonal (Concentrated) (Y85) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated, Concentrated
1 ml/$2,153
PR / Progesterone Receptor Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
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PR / Progesterone Receptor Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
PR / Progesterone Receptor ELISA Kit
Select
Sandwich
12 x 8-Well Microstrips
Mouse
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
PR / Progesterone Receptor Antibody - PGR/PR/Progesterone Receptor antibody. IHC(P): Human Lung Cancer Tissue.
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PR / Progesterone Receptor Rabbit anti-Human Polyclonal (aa595-933) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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PR / Progesterone Receptor Mouse anti-Human Monoclonal (aa919-933) (C262) Antibody
Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Horse, Human, Monkey
IP, WB
Unconjugated
0.05 mg/$429
PR / Progesterone Receptor Antibody - IHC of paraffin-embedded Human breast tissue using anti-PGR mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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PR / Progesterone Receptor Mouse anti-Human Monoclonal (aa1-298) (Carrier-free) (OTI11E8) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PR / Progesterone Receptor Antibody - Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human endometrium. [antibody concentration 1.5 ug/ml]
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PR / Progesterone Receptor Mouse anti-Human Monoclonal (2C2) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$423
PR / Progesterone Receptor Antibody - PGR / Progesterone Receptor antibody Western blot of Mouse Thymus lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PR / Progesterone Receptor Rabbit anti-Mouse Polyclonal (aa201-250) Antibody
Mouse
WB
Unconjugated
100 µl/$424
PR / Progesterone Receptor Antibody - IHC of paraffin-embedded Human breast tissue using anti-PGR mouse monoclonal antibody. (heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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PR / Progesterone Receptor Mouse anti-Human Monoclonal (aa1-298) (OTI4B3) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
PR / Progesterone Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
PR / Progesterone Receptor Protein - Recombinant Progesterone Receptor (PGR) by SDS-PAGE
Select
E. coli
His, N-terminus
20.4 kDa
10 µg/$275; 50 µg/$402; 200 µg/$805; 100 µg/$645; 1 mg/$1,881; 500 µg/$1,435; 5 mg/$2,844; 2 mg/$2,065
PR / Progesterone Receptor Antibody - Anti-PGR / Progesterone Receptor antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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PR / Progesterone Receptor Rabbit anti-Human Polyclonal (aa371-420) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
PR / Progesterone Receptor Antibody - Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using Progesterone Receptor Antibody. The picture on the right is blocked with the synthesized peptide.
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PR / Progesterone Receptor Rabbit anti-Human Polyclonal (aa261-310) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
PR / Progesterone Receptor Antibody - IHC of Progesterone Receptor on FFPE Breast Carcinoma tissue.
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PR / Progesterone Receptor Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$371; 0.5 ml/$665; 1 ml/$952
PR / Progesterone Receptor Antibody - Western blot of whole cell T47D lysate prepared from cells that had been incubated in the presence of the synthetic progestin agonist R5020 (500 nM) showing specific immunolabeling of the -90k PR-A isoform and the -120 PR-13 isoform of the progesterone re.
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PR / Progesterone Receptor Mouse anti-Human Monoclonal (pSer294) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µl/$469
PR / Progesterone Receptor Antibody - Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human breast cancer. [antibody concentration 3 ug/ml]
Select
PR / Progesterone Receptor Mouse anti-Human Monoclonal (3E11) Antibody
Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$423
PR / Progesterone Receptor Antibody - Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human endometrium. [antibody concentration 1.5 ug/ml]
Select
PR / Progesterone Receptor Mouse anti-Human Monoclonal (1B11) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$423
PR / Progesterone Receptor Antibody - Immunoperoxidase of monoclonal antibody to PGR on formalin-fixed paraffin-embedded human breast cancer. [antibody concentration 3 ug/ml]
Select
PR / Progesterone Receptor Mouse anti-Human Monoclonal (5D10) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$423
PR / Progesterone Receptor Antibody - Immunohistochemical analysis of Progesterone Receptor staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
PR / Progesterone Receptor Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$321
PR / Progesterone Receptor Antibody - Immunohistochemical analysis of Progesterone Receptor (pS190) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
PR / Progesterone Receptor Rabbit anti-Human Polyclonal (pSer190) Antibody
Human, Monkey
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
Select
PR / Progesterone Receptor Rabbit anti-Human Monoclonal (EP2) Antibody
Human
IHC-Fr, IHC-P
Unconjugated
0.1 ml/$488; 0.5 ml/$1,059; 1 ml/$1,505
Viewing 1-25 of 274 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).