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RAB7A / RAB7

RAB7A, member RAS oncogene family

Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA. Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation.

Gene Name: RAB7A, member RAS oncogene family
Synonyms: RAB7A, CMT2B, PRO2706, RAB7, Ras-associated protein RAB7, Ras-related protein Rab-7a, PSN
Target Sequences: NM_004637 AAA86640.1 P51149

Publications (1)

1
IC/BPS-associated alterations of M2 and M3 muscarinic acetylcholine receptor trafficking in human detrusor. Mandy Berndt-Paetz, Luise Herbst, Annett Weimann, Andreas Gonsior, Jens-Uwe Stolzenburg, Jochen Neuhaus. Neurourology and urodynamics. 2019 September;38:1818-1827. [Full Text Article] [PubMed:31301091] Related Antibodies: LS-B13237.

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RAB7A / RAB7 (41)
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RAB7A / RAB7 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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RAB7A / RAB7 Goat anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$460
RAB7A / RAB7 Antibody - Anti-RAB7 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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RAB7A / RAB7 Rabbit anti-Human Polyclonal (aa90-140) Antibody
Xenopus, Chicken, Zebrafish, Rat, Rabbit, Mouse, Dog, Bovine, Human, Monkey
ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$460
RAB7A / RAB7 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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RAB7A / RAB7 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
RAB7A / RAB7 Antibody - ICC/IF analysis of RAB7A in HeLa cells. The cell was stained with RAB7A antibody (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).
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RAB7A / RAB7 Mouse anti-Human Monoclonal (AT10E4) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
50 µl/$303; 100 µl/$365
RAB7A / RAB7 Antibody - Immunohistochemistry of paraffin-embedded human gastric cancer tissue using RAB7A Antibody at dilution of 1:100
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RAB7A / RAB7 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
RAB7A / RAB7 Antibody - Formalin-fixed and paraffin-embedded human skeletal muscle reacted with RAB7 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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RAB7A / RAB7 Rabbit anti-Human Polyclonal (aa176-204) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
RAB7A / RAB7 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
RAB7A / RAB7 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
RAB7A / RAB7 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
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RAB7A / RAB7 Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
RAB7A / RAB7 Antibody - Immunochemical staining of human RAB7A in human kidney with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.
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RAB7A / RAB7 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC-P
Unconjugated
100 µl/$412
RAB7A / RAB7 Antibody - 1:100 staining mouse muscle tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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RAB7A / RAB7 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
RAB7A / RAB7 Antibody - Anti-RAB7A rabbit polyclonal antibody at 1:500 dilution. Lane A: A431 Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG H&L (Dylight 800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 23 kDa. Observed band size: 23 kDa.
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RAB7A / RAB7 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, WB
Unconjugated, Preservative Free
100 µl/$412
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RAB7A / RAB7 Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$412
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RAB7A / RAB7 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
RAB7A / RAB7 Antibody - 1:100 staining mouse muscle tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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RAB7A / RAB7 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
RAB7A / RAB7 Antibody - Western blot of RAB7A pAb in extracts from K562 cells.
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RAB7A / RAB7 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
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RAB7A / RAB7 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
0.1 mg/$379
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RAB7A / RAB7 Rabbit anti-Human Polyclonal (aa176-204) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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RAB7A / RAB7 Rabbit anti-Human Polyclonal (aa176-204) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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RAB7A / RAB7 Rabbit anti-Human Polyclonal (aa176-204) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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RAB7A / RAB7 Rabbit anti-Human Polyclonal (aa176-204) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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RAB7A / RAB7 Rabbit anti-Human Polyclonal (aa176-204) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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RAB7A / RAB7 Rabbit anti-Human Polyclonal (aa176-204) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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RAB7A / RAB7 Rabbit anti-Human Polyclonal (Asp193) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$688
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RAB7A / RAB7 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Viewing 1-25 of 41 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).