RASA1

RAS p21 protein activator (GTPase activating protein) 1

RASA1 is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.

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Products

Proteins (8)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Recombinant (4)

Target

RASA1 (8)

Publications

No (8)

Tag

6His, N-terminus (2)

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human RASA1 Protein (Over-Expression Lysate 6His, N-terminus) (Met2-Arg1047) - LS-G26814

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

100 kDa

Price:

100 µg/$298

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Human RASA1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65806

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

116.2 kDa

Price:

20 µg/$1,107

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Human RASA1 Protein (Recombinant GST, N-terminus) (aa948-1047) - LS-G59872

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RASA1 Protein (Recombinant His-T7) (aa403-596) - LS-G24388

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.5 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human RASA1 Protein (Over-Expression Cell Culture Supernatant 6His, N-terminus) (Met2-Arg1047) - LS-G26950

Source:

HEK 293 Cells

Tag:

6His, N-terminus

Molecular Weight:

100 kDa

Price:

200 µl/$283

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Human RASA1 Protein (Recombinant GST) (Full Length) - LS-G30125

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

126.8 kDa

Price:

2 µg/$439

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RASA1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99898

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

116.2 kDa

Price:

100 µg/$494

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Human RASA1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76327

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

116.2 kDa

Price:

20 µg/$150

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