RELA / NFKB p65

v-rel avian reticuloendotheliosis viral oncogene homolog A

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1.

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Products

Proteins (10)

Type

Over-Expression Lysate (2)

Recombinant (8)

Target

RELA / NFKB p65 (10)

Publications

No (10)

Tag

GST (2)

GST, N-terminus (2)

His (1)

His, N-Terminal (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (8)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Sf21 Cells (1)

Wheat Germ Extract (3)

Purification

Purified (3)

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Mouse RELA / NFKB p65 Protein (Recombinant His, N-Terminal) (aa19-306) - LS-G12527

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

36.8 kDa

Price:

10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796

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Human RELA / NFKB p65 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79230

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60 kDa

Price:

20 µg/$215

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Human RELA / NFKB p65 Protein (Recombinant GST) (Full Length) - LS-G30146

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

51.2 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RELA / NFKB p65 Protein (Recombinant GST) (Full Length) - LS-G30145

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

49.83 kDa

Price:

10 µg/$479; 25 µg/$670

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Human RELA / NFKB p65 Protein (Recombinant GST, N-terminus) (aa432-505) - LS-G59896

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RELA / NFKB p65 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67148

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60 kDa

Price:

20 µg/$1,107

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RELA / NFKB p65 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101779

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60 kDa

Price:

100 µg/$710

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Human RELA / NFKB p65 Protein (Recombinant GST, N-terminus) (Met1-Tyr306) - LS-G137970

Source:

E. coli

Tag:

GST, N-terminus

Molecular Weight:

62 kDa

Price:

100 µg/$661

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Human RELA / NFKB p65 Protein (Recombinant His) - LS-G4016

Source:

Sf21 Cells

Tag:

His

Price:

2 µg/$414

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Human RELA / NFKB p65 Protein (Recombinant His-T7) (aa19-306) - LS-G12528

Source:

E. coli

Tag:

His-T7

Molecular Weight:

36.6 kDa

Price:

10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278

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