RORC / ROR Gamma

RAR-related orphan receptor C

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A. Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays also a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC and PCK1. Regulates the rhythmic expression of PROX1 and promotes its nuclear localization.

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Products

Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

RORC / ROR Gamma (10)

Publications

No (10)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

His-SUMO (1)

His-T7 (1)

Myc-DDK (Flag) (5)

Species

Human (7)

Mouse (1)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (2)

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Mouse RORC / ROR Gamma Protein (Recombinant 6His, N-terminus) (aa1-516) - LS-G57248

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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Human RORC / ROR Gamma Protein (Recombinant His-T7) (aa212-461) - LS-G15429

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.6 kDa

Price:

10 µg/$280; 50 µg/$435; 100 µg/$695; 200 µg/$870; 1 mg/$1,972; 500 µg/$1,514; 5 mg/$3,039; 2 mg/$2,159

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Human RORC / ROR Gamma Protein (Recombinant His-SUMO) (Full Length) - LS-G21139

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

74.2 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human RORC / ROR Gamma Protein (Recombinant GST) (Full Length) - LS-G30193

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

84.6 kDa

Price:

2 µg/$439

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Human RORC / ROR Gamma Protein (Recombinant GST, N-terminus) (aa412-517) - LS-G59933

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human RORC / ROR Gamma Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66458

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58 kDa

Price:

20 µg/$1,107

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RORC / ROR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100452

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58 kDa

Price:

100 µg/$494

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Human RORC / ROR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77762

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.6 kDa

Price:

20 µg/$215

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Human RORC / ROR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77763

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58 kDa

Price:

20 µg/$150

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RORC / ROR Gamma Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122843

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.6 kDa

Price:

100 µg/$710

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