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S100B / S100 Beta
S100 calcium binding protein B
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
| Gene Name: | S100 calcium binding protein B |
| Synonyms: | S100B, NEF, Protein S100-B, S100, S100 calcium binding protein B, S100 calcium-binding protein B, S100beta, S-100 protein beta chain, S-100 protein subunit beta, S100-B |
| Target Sequences: | NM_006272 NP_006263.1 P04271 |
Publications (3)
1
Striatal astrocytes engulf dopaminergic debris in Parkinson's disease: A study in an animal model. Morales I, Sanchez A, Rodriguez-Sabate C, Rodriguez M,. PloS one. 2017 12:e0185989. (WB; Human)
[Full Text Article]
[PubMed:29028815]
2
The astrocytic response to the dopaminergic denervation of the striatum. Morales I, Sanchez A, Rodriguez-Sabate C, Rodriguez M. Journal of neurochemistry. 2016 October;139:81-95. [Full Text Article]
[PubMed:27230040]
3
Neuroglial transmitophagy and Parkinson's disease. Ingrid Morales, Alberto Sanchez, Ricardo Puertas-Avendaño, Clara Rodriguez-Sabate, Adrian Perez-Barreto, Manuel Rodriguez. Glia. 2020 November;68:2277-2299. [Full Text Article]
[PubMed:32415886]
☰ Filters
Products
Proteins
(28)
Type
Native
(2)
Over-Expression Cell Culture Supernatant
(1)
Over-Expression Lysate
(3)
Recombinant
(22)
Target
S100B / S100 Beta
(28)
Application
Bind
(2)
ELISA
(2)
Func
(2)
SDS-PAGE
(3)
Publications
No
(28)
Tag
6His, C-terminus
(2)
6His, N-terminus
(5)
Fc
(1)
Fc, N-terminus
(1)
GST
(2)
His
(7)
His, N-Terminal
(2)
His,N-terminus
(1)
His-GST
(1)
His-T7
(1)
Human IgG1 Fc, N-terminus
(2)
Myc-DDK (Flag)
(3)
Species
Bovine
(1)
Human
(16)
Mouse
(7)
Rabbit
(1)
Rat
(2)
Source
293T Cells
(1)
E. coli
(15)
HEK 293 Cells
(7)
Human Cells
(1)
Mouse
(1)
Rat
(1)
Wheat Germ Extract
(2)
Purification
Purified
(7)
Low Endotoxin Level
Low endotoxin level
(9)
Biologically Active
Biologically active
(3)
E. coli
6His, N-terminus
12.5 kDa
50 µg/$315; 100 µg/$365
E. coli
His
12.3 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
HEK 293 Cells
Human IgG1 Fc, N-terminus
SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant mouse S100B/Fc comprises 351 amino acids and has a predicted molecular mass of 39 kDa. The apparent molecular mass of the protein is approximately 41 kDa in SDS-PAGE under reducing conditions due to glycosylation.
100 µg/$441
HEK 293 Cells
Human IgG1 Fc, N-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human Fc/S100B is a disulfide-linked homodimeric protein. The reduced monomer consists of 328 amino acids and has a predicted molecular mass of 37.2 kDa. As a result of glycosylation, the apparent molecular mass of rhFc/S100B monomer is approximately 40 kDa in SDS-PAGE under reducing conditions.
100 µg/$441
HEK 293 Cells
6His, N-terminus
13 kDa
200 µl/$283
E. coli
His
100 µg/$342; 500 µg/$641; 20 µg/$254
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
11.8kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
12.2kD
10 µg/$266; 50 µg/$343; 500 µg/$1,377; 1 mg/$1,765
Wheat Germ Extract
GST
37.1 kDa
10 µg/$479; 25 µg/$670
Wheat Germ Extract
GST
35.86 kDa
10 µg/$479; 25 µg/$670
E. coli
His,N-terminus
Bind ELISA Func SDS-PAGE
Biologically active
The recombinant human S100B consisting of 102 amino acids and migrates as an approximately 12 kDa band in SDS-PAGE under reducing conditions as predicted.
100 µg/$441; 1 mg/$2,003
Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
37.2 kDa
100 µg/$721
293T Cells
Myc-DDK (Flag)
10.5 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
10.5 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
10.5 kDa
100 µg/$494
HEK 293 Cells
Fc, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
39 kDa
100 µg/$721
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
11.8 kDa
10 µg/$281; 50 µg/$389
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
12.2 kDa
10 µg/$266; 50 µg/$339
Mouse
His, N-Terminal
10kDa
10 µg/$291; 50 µg/$502; 200 µg/$1,002; 100 µg/$802; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
E. coli
92 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
10.12 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
HEK 293 Cells
6His, N-terminus
13 kDa
100 µg/$298
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
E. coli
His
12 kDa
100 µg/$721
Rat
His, N-Terminal
12kDa
10 µg/$291; 50 µg/$502; 200 µg/$1,002; 100 µg/$802; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
E. coli
His-GST
43.1 kDa
50 µg/$492; 10 µg/$289; 200 µg/$982; 100 µg/$785; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
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