SDF1 / CXCL12

chemokine (C-X-C motif) ligand 12

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

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Products

ELISA Kits (31)

Type

Competitive EIA (1)

Custom (1)

Development Kit (1)

Sandwich (25)

Sandwich CLIA (3)

Target

SDF1 / CXCL12 (31)

Reactivity

Human (10)

Mouse (9)

Rat (7)

Chicken (1)

Guinea pig (1)

Pig (2)

Rabbit (1)

Product Group

DevKit DuoPlus (1)

Format

12 x 8-Well Microstrips (2)

96-Well Microplate (7)

96-Well Strip Plate (21)

Antibody Pair and Standard (1)

Publications

No (30)

Yes (1)

Sample Type

Cell Culture Supernatants (12)

Cell Lysates (6)

Cell Supernatant (1)

Plasma (29)

Serum (28)

Tissue Homogenates (13)

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Human SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F3387

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

32.77 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$534

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Human SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F5180

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$573

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Mouse SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F5181

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$782

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Rat SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F5502

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$715

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Pig SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F9716

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$779

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Human SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F12575

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$585

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Rat SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F21608

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.16 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F3386

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

93.75 - 6000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma

Price:

1 Plate/$426

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Rat SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F56575

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

15.625 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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DevKit DuoPlus Human SDF1 / CXCL12 ELISA Development Kit - LS-F71430

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

500 Wells/$1,043; 1000 Wells/$1,514

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Mouse SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F37151

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rabbit SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F50777

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

0.625 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$1,002

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Mouse SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F3431

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

9.375 - 300 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$534

Select

Rat SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F55257

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$776

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Rat SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F74834

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.31 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Supernatant, Plasma, Serum

Price:

1 Plate/$598

Select

Mouse SDF1 / CXCL12 (Custom ELISA) ELISA Kit - LS-F14621

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$585

Select

Chicken SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F21735

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Chicken

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Human SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F20851

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Mouse SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F23860

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Mouse

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

Select

Mouse SDF1 / CXCL12 (CLIA) ELISA Kit - LS-F30959

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Human SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F37148

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat SDF1 / CXCL12 (CLIA) ELISA Kit - LS-F37734

Type:

Sandwich CLIA

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

Select

Human SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F27217

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.5 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Rat SDF1 / CXCL12 (Sandwich ELISA) ELISA Kit - LS-F27586

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.5 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

Select

Mouse SDF1 / CXCL12 (Competitive EIA) ELISA Kit - LS-F28593

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.5 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

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