SDF1 / CXCL12

chemokine (C-X-C motif) ligand 12

Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.

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Products

Proteins (52)

Type

Over-Expression Lysate (2)

Recombinant (50)

Target

SDF1 / CXCL12 (52)

Application

Bind (1)

ELISA (1)

Func (1)

SDS-PAGE (5)

Format

Animal-free (2)

Publications

No (52)

Tag

GST (1)

His (3)

His, N-Terminal (1)

His,N-terminus (1)

His-GST (2)

His-GST, N-terminus (1)

Human IgG1 Fc, N-terminus (2)

Myc-DDK (Flag) (3)

Species

Human (32)

Mouse (14)

Rat (5)

Source

293T Cells (1)

CHO Cells (1)

E. coli (43)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Purification

Purified (25)

Low Endotoxin Level

Low endotoxin level (29)

Biologically Active

Biologically active (26)

Animal-free

Animal-free (2)

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Mouse SDF1 / CXCL12 Protein (Recombinant) (Lys22-Lys89) - LS-G27012

Source:

CHO Cells

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.2 EU/µg protein (determined by LAL method).

Molecular Weight:

8 kDa (SDS-PAGE)

Price:

5 µg/$304; 25 µg/$402

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Human SDF1 / CXCL12 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67035

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

9.9 kDa

Price:

20 µg/$1,107

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Mouse SDF1 / CXCL12 Protein (Recombinant) - LS-G227

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

7.9 kDa

Price:

2 µg/$268; 10 µg/$349

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Mouse SDF1 / CXCL12 Protein (Recombinant) - LS-G230

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

8.5 kDa

Price:

2 µg/$268; 10 µg/$349

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Human SDF1 / CXCL12 Protein (Recombinant) - LS-G283

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

8.5 kDa

Price:

2 µg/$268; 10 µg/$349

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Human SDF1 / CXCL12 Protein (Recombinant) - LS-G3678

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).

Price:

2 µg/$282; 10 µg/$370

• Unmodified
• Animal-free

• Unmodified
• Animal-free

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Human SDF1 / CXCL12 Protein (Recombinant) - LS-G284

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

8.0 kDa

Price:

2 µg/$268; 10 µg/$349

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Human SDF1 / CXCL12 Protein (Recombinant) - LS-G3677

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).

Price:

2 µg/$281; 10 µg/$369

• Unmodified
• Animal-free

• Unmodified
• Animal-free

Select

Rat SDF1 / CXCL12 Protein (Recombinant) - LS-G423

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

7.9 kDa

Price:

2 µg/$268; 10 µg/$349

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Rat SDF1 / CXCL12 Protein (Recombinant) - LS-G425

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

8.4 kDa

Price:

2 µg/$268; 10 µg/$349

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Human SDF1 / CXCL12 Protein (Recombinant) (aa21-119) - LS-G5623

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

11.6 kDa

Price:

10 µg/$388; 500 µg/$1,747; 100 µg/$957

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Human SDF1 / CXCL12 Protein (Recombinant) (aa22-89) - LS-G5619

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

8.0 kDa

Price:

10 µg/$388; 100 µg/$957; 500 µg/$1,747

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Human SDF1 / CXCL12 Protein (Recombinant) (aa22-93) - LS-G5621

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

8.5 kDa

Price:

10 µg/$388; 100 µg/$957; 500 µg/$1,747

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Mouse SDF1 / CXCL12 Protein (Recombinant) (aa22-89) - LS-G5662

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

8.0 kDa

Price:

10 µg/$388; 100 µg/$957; 500 µg/$1,747

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Mouse SDF1 / CXCL12 Protein (Recombinant) (aa22-93) - LS-G5665

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

8.5 kDa

Price:

10 µg/$388; 100 µg/$957; 500 µg/$1,747

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Rat SDF1 / CXCL12 Protein (Recombinant) (aa22-89) - LS-G5694

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

7.9 kDa

Price:

10 µg/$388; 100 µg/$1,116; 500 µg/$2,095

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Rat SDF1 / CXCL12 Protein (Recombinant) (aa22-89) - LS-G5695

Source:

E. coli

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

8.4 kDa

Price:

10 µg/$388; 100 µg/$1,116; 500 µg/$2,095

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Human SDF1 / CXCL12 Protein (Recombinant His) (aa23-89) - LS-G11602

Source:

E. coli

Tag:

His

Molecular Weight:

9.9 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Mouse SDF1 / CXCL12 Protein (Recombinant His) (aa22-89) - LS-G11610

Source:

E. coli

Tag:

His

Molecular Weight:

9.5 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Human SDF1 / CXCL12 Protein (Recombinant His-GST) (aa23-89) - LS-G11611

Source:

E. coli

Tag:

His-GST

Molecular Weight:

40.2 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Rat SDF1 / CXCL12 Protein (Recombinant His-GST) (aa21-89) - LS-G11612

Source:

E. coli

Tag:

His-GST

Molecular Weight:

40.4 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human SDF1 / CXCL12 Protein (Recombinant) - LS-G37728

Tag:

None

Molecular Weight:

8.0 kD

Price:

10 µg/$476

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Mouse SDF1 / CXCL12 Protein (Recombinant) - LS-G37846

Tag:

None

Biological Activity:

Biologically active

Molecular Weight:

7.9 kD

Price:

10 µg/$484

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Human SDF1 / CXCL12 Protein (Recombinant GST) (Full Length) - LS-G30363

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

35.53 kDa

Price:

2 µg/$439

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Human SDF1 / CXCL12 Protein (Recombinant Human IgG1 Fc, N-terminus) (Lys22-Met93) - LS-G47814

Source:

HEK 293 Cells

Tag:

Human IgG1 Fc, N-terminus

Application:

Bind ELISA Func SDS-PAGE

Biological Activity:

Biologically active

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

The recombinant human SDF1/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 309 amino acids and predicts a molecular mass of 35.2 kDa. As a result of glycosylation, rhSDF1/Fc monomer is approximately 43 kDa in SDS-PAGE under reducing conditions.

Price:

50 µg/$364

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