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SEMA3A / Semaphorin 3A

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

SEMA3A / Semaphorin 3A is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.

Gene Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Synonyms: SEMA3A, Collapsin 1, Coll-1, Hsema-III, Hsema-I, Sema III, SEMAIII, SEMAL, Semaphorin III, Semaphorin-3A, Semaphorin-iii (hsema-i), SemD, SEMA1, Semaphorin D, COLL1, SEMAD, Semaphorin 3A, Semaphorin L, SEM3A
Target Sequences: NM_006080 NP_006071.1 Q14563

Publications (1)

1
Myeloid-resident neuropilin-1 promotes choroidal neovascularization while mitigating inflammation. Elisabeth M M A Andriessen, François Binet , Frédérik Fournier, Masayuki Hata, Agnieszka Dejda, Gaëlle Mawambo, Sergio Crespo-Garcia , Frédérique Pilon, Manuel Buscarlet, Karine Beauchemin, Véronique Bougie, Garth Cumberlidge, Ariel M Wilson, Steve Bourgault, Flavio A Rezende, Normand Beaulieu, Jean-Sébastien Delisle, Przemyslaw Sapieha. EMBO molecular medicine. 2021 May;13:e11754. [Full Text Article] [PubMed:33876574] [PMC:PMC8103107]

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Proteins (13)
Over-Expression Lysate (2)
Recombinant (11)
SEMA3A / Semaphorin 3A (13)
No (13)
6His, N-terminus (1)
6His-Flag, C-terminus (1)
Fc (1)
GST, N-terminus (1)
His, N-Terminal (1)
His, N-terminus + Human IgG Fc, C-terminus (1)
His/Flag,N-terminus (1)
His-T7 (4)
Myc-DDK (Flag) (2)
Human (8)
Mouse (2)
Rat (2)
293T Cells (1)
CHO Cells (1)
E. coli (6)
HEK 293 Cells (1)
Human Cells (1)
Mammalian Cells (2)
Wheat Germ Extract (1)
Purified (4)
Low endotoxin level (3)
Biologically active (1)
SEMA3A / Semaphorin 3A Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
SEMA3A / Semaphorin 3A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
88.89 kDa
20 µg/$215
SEMA3A / Semaphorin 3A Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
88.89 kDa
100 µg/$710
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Human Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
87.7 kDa
50 µg/$502
SEMA3A / Semaphorin 3A Protein - Active Semaphorin 3A (SEMA3A) by WB
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E. coli
His, N-Terminal
16kDa
10 µg/$306; 50 µg/$600; 200 µg/$1,152; 100 µg/$957; 1 mg/$2,365; 500 µg/$1,871; 5 mg/$4,187; 2 mg/$2,557
SEMA3A / Semaphorin 3A Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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Mammalian Cells
6His-Flag, C-terminus
Less than 0.1 ng/mL (Less than 1 EU/µg) (determined by LAL method).
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
Select
CHO Cells
His, N-terminus + Human IgG Fc, C-terminus
Biologically active
226.2 kDa or 200 kDa or 120-130 kDa, 90-100 kDa, and 35-40 kDa
5 µg/$268; 25 µg/$349
SEMA3A / Semaphorin 3A Protein - Recombinant Semaphorin 3A By SDS-PAGE
Select
E. coli
His-T7
13.9 kDa
10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934
SEMA3A / Semaphorin 3A Protein
Select
E. coli
His-T7
16.7 kDa
10 µg/$268; 50 µg/$362; 100 µg/$577; 200 µg/$722; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934
SEMA3A / Semaphorin 3A Protein - Recombinant Semaphorin 3A By SDS-PAGE
Select
E. coli
His-T7
17.7 kDa
10 µg/$279; 50 µg/$430; 100 µg/$687; 200 µg/$857; 1 mg/$1,956; 500 µg/$1,499; 5 mg/$2,997; 2 mg/$2,142
SEMA3A / Semaphorin 3A Protein - Recombinant Semaphorin 3A By SDS-PAGE
Select
E. coli
His-T7
17.7 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
Select
Mammalian Cells
His/Flag,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
61.3 kDa
10 µg/$288; 50 µg/$436
Viewing 1-13 of 13 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).