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Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Gene Name: | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 |
Synonyms: | SERPINF1, EPC-1, OI12, PEDF, Serpin F1, PIG35, OI6 |
Target Sequences: | NM_002615 NP_002606.3 P36955 |
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