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SLC7A11 / XCT

solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11

SLC7A11 / XCT is a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

Gene Name: solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Family/Subfamily: Transporter , Cationic amino acid transporter
Synonyms: SLC7A11, CCBR1, Cystine/glutamate transporter, XCT, SLC711
Target Sequences: NM_014331 NP_055146.1 Q9UPY5

Publications (12)

1
Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. Liu R, Blower PE, Pham AN, Fang J, Dai Z, Wise C, Green B, Teitel CH, Ning B, Ling W, Lyn-Cook BD, Kadlubar FF, Sade W, Huang Y. Molecular pharmacology. 2007 72:1637-46. (WB; Human) [PubMed:17875604]
2
Glutamate, excitatory amino acid transporters, Xc- antiporter, glutamine synthetase, and gamma-glutamyltranspeptidase in human corneal epithelium. Langford MP, Redmond P, Chanis R, Misra RP, Redens TB. Current eye research. 2010 35:202-11. (ICC; Human) [PubMed:20373878]
3
Astrocytic redox remodeling by amyloid beta peptide. Garg SK, Vitvitsky V, Albin R, Banerjee R. Antioxidants & redox signaling. 2011 14:2385-97. (WB; Mouse) [PubMed:21235355] [PMC:PMC3096517]
4
Role of the Nrf2-ARE pathway in acrylamide neurotoxicity. Zhang L, Gavin T, Barber DS, LoPachin RM. Toxicology letters. 2011 205:7-Jan. (WB; Rat) [PubMed:21540084] [PMC:PMC3149808]
5
Activated human CD4+ T cells express transporters for both cysteine and cystine. Levring TB, Hansen AK, Nielsen BL, Kongsbak M, von Essen MR, Woetmann A, Odum N, Bonefeld CM, Geisler C. Scientific reports. 2012 2:266. [PubMed:22355778] [PMC:PMC3278673]
6
Extracellular human immunodeficiency virus type 1 viral protein R causes reductions in astrocytic ATP and glutathione levels compromising the antioxidant reservoir. Ferrucci A, Nonnemacher MR, Cohen EA, Wigdahl B. Virus research. 2012 167:358-69. (ICC; Human) [PubMed:22691542] [PMC:PMC3398186]
7
Exploratory clinical trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for imaging xC- transporter using positron emission tomography in patients with non-small cell lung or breast cancer. Baek S, Choi CM, Ahn SH, Lee JW, Gong G, Ryu JS, Oh SJ, Bacher-Stier C, Fels L, Koglin N, Hultsch C, Schatz CA, Dinkelborg LM, Mittra ES, Gambhir SS, Moon DH. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012 18:5427-37. (IHC; Human) [PubMed:22893629]
8
Early intraarticular injection of hyaluronic acid attenuates osteoarthritis progression in anterior cruciate ligament-transected rats. Tsai WY, Wu JL, Liu CC, Cherng CH, Tsai RY, Jean YH, Wong CS. Connective tissue research. 2013 54:49-54. (WB; Human) [PubMed:23020698]
9
The pharmacologic inhibition of the xc- antioxidant system improves the antitumor efficacy of COX inhibitors in the in vivo model of 3-MCA tumorigenesis. Balza E, Castellani P, Delfino L, Truini M, Rubartelli A. Carcinogenesis. 2013 34:620-6. [PubMed:23161574]
10
(4S)-4-(3-18F-fluoropropyl)-L-glutamate for imaging of xC transporter activity in hepatocellular carcinoma using PET: preclinical and exploratory clinical studies. Baek S, Mueller A, Lim YS, Lee HC, Lee YJ, Gong G, Kim JS, Ryu JS, Oh SJ, Lee SJ, Bacher-Stier C, Fels L, Koglin N, Schatz CA, Dinkelborg LM, Moon DH. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2013 54:117-23. [PubMed:23232273]
11
A functional microRNA library screen reveals miR-410 as a novel anti-apoptotic regulator of cholangiocarcinoma. Palumbo T, Poultsides GA, Kouraklis G, Liakakos T, Drakaki A, Peros G, Hatziapostolou M, Iliopoulos D. BMC cancer. 2016 16:353. (WB; Mouse) [Full Text Article] [PubMed:27259577] [PMC:PMC4893280]
12
Increased Expression of System xc- in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance. Polewski MD, Reveron-Thornton RF, Cherryholmes GA, Marinov GK, Cassady K, Aboody KS. Molecular cancer research : MCR. 2016 December;14:1229-1242. (Human) [Full Text Article] [PubMed:27658422] [PMC:PMC6237285] Related Antibodies: LS-B4345.
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SLC7A11 / XCT Antibody - Anti-SLC7A11 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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PathPlus™ SLC7A11 / XCT Antibody (aa215-229) LS-B4345
Neuroscience
(5.0) Rating
(1) Publication(s)
SLC7A11 / XCT Goat anti-Human Polyclonal (aa215-229) Antibody
Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
SLC7A11 / XCT Antibody - Anti-SLC7A11 antibody IHC of human stomach. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ SLC7A11 / XCT Antibody (N-Terminus) LS-A3053
Neuroscience
Fast Shipping
(5.0) Rating
SLC7A11 / XCT Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
SLC7A11 / XCT Antibody - Anti-SLC7A11 antibody IHC of human chief cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ SLC7A11 / XCT Antibody (N-Terminus) LS-A3434
Neuroscience
Fast Shipping
(5.0) Rating
SLC7A11 / XCT Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
SLC7A11 / XCT Antibody - SLC7A11 antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SLC7A11 / XCT Antibody (aa215-264) LS-C110838
SLC7A11 / XCT Rabbit anti-Human Polyclonal (aa215-264) Antibody
Human
WB
Unconjugated
100 µl/$424
SLC7A11 / XCT Antibody - SLC7A11 antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SLC7A11 / XCT Antibody (aa215-264, HRP) LS-C445840
SLC7A11 / XCT Rabbit anti-Human Polyclonal (aa215-264) (HRP) Antibody
Mouse, Rat, Pig, Orangutan, Gibbon, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100 µl/$469
SLC7A11 / XCT Antibody - SLC7A11 antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SLC7A11 / XCT Antibody (aa215-264, Biotin) LS-C445839
SLC7A11 / XCT Rabbit anti-Human Polyclonal (aa215-264) (Biotin) Antibody
Mouse, Rat, Pig, Orangutan, Gibbon, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
SLC7A11 / XCT Antibody - SLC7A11 antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SLC7A11 / XCT Antibody (aa215-264, FITC) LS-C445841
SLC7A11 / XCT Rabbit anti-Human Polyclonal (aa215-264) (FITC) Antibody
Mouse, Rat, Pig, Orangutan, Gibbon, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100 µl/$469
SLC7A11 / XCT Antibody - 1:100 staining human thyroid carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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SLC7A11 / XCT Antibody LS-C803000
SLC7A11 / XCT Rabbit anti-Human Polyclonal Antibody
Mouse, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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SLC7A11 / XCT Antibody LS-C770686
SLC7A11 / XCT Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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SLC7A11 / XCT Antibody LS-C829218
SLC7A11 / XCT Rabbit-New Zealand White anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
100 µl/$393
SLC7A11 / XCT Antibody - Detection of XCT in total human stomach lysate using NB 300-317. 15 minute ECL exposure. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SLC7A11 / XCT Antibody (N-Terminus, Biotin) LS-C142123
SLC7A11 / XCT Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Human
Flo, WB
Biotin Conjugated
0.1 ml/$416
SLC7A11 / XCT Antibody - Detection of XCT in total human stomach lysate using NB 300-317. 15 minute ECL exposure. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SLC7A11 / XCT Antibody (N-Terminus, DY488) LS-C142125
SLC7A11 / XCT Rabbit anti-Human Polyclonal (N-Terminus) (DY488) Antibody
Human
Flo, WB
DY488 Conjugated
0.1 ml/$416
SLC7A11 / XCT Antibody - Detection of XCT in total human stomach lysate using NB 300-317. 15 minute ECL exposure. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SLC7A11 / XCT Antibody (N-Terminus, DY550) LS-C142127
SLC7A11 / XCT Rabbit anti-Human Polyclonal (N-Terminus) (DY550) Antibody
Human
Flo, WB
DY550 Conjugated
0.1 ml/$416
SLC7A11 / XCT Antibody - Detection of XCT in total human stomach lysate using NB 300-317. 15 minute ECL exposure. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SLC7A11 / XCT Antibody (N-Terminus, DY650) LS-C142124
SLC7A11 / XCT Rabbit anti-Human Polyclonal (N-Terminus) (DY650) Antibody
Human
Flo, WB
DY650 Conjugated
0.1 ml/$416
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SLC7A11 / XCT Antibody (N-Terminus) LS-C89187
SLC7A11 / XCT Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$649
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SLC7A11 / XCT Antibody LS-C748722
SLC7A11 / XCT Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
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