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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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SLC7A11 / XCT
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A11 / XCT is a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.
Gene Name:
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. Liu R, Blower PE, Pham AN, Fang J, Dai Z, Wise C, Green B, Teitel CH, Ning B, Ling W, Lyn-Cook BD, Kadlubar FF, Sade W, Huang Y. Molecular pharmacology. 2007 72:1637-46. (WB; Human)
[PubMed:17875604]
2
Glutamate, excitatory amino acid transporters, Xc- antiporter, glutamine synthetase, and gamma-glutamyltranspeptidase in human corneal epithelium. Langford MP, Redmond P, Chanis R, Misra RP, Redens TB. Current eye research. 2010 35:202-11. (ICC; Human)
[PubMed:20373878]
Role of the Nrf2-ARE pathway in acrylamide neurotoxicity. Zhang L, Gavin T, Barber DS, LoPachin RM. Toxicology letters. 2011 205:7-Jan. (WB; Rat)
[PubMed:21540084]
[PMC:PMC3149808]
5
Activated human CD4+ T cells express transporters for both cysteine and cystine. Levring TB, Hansen AK, Nielsen BL, Kongsbak M, von Essen MR, Woetmann A, Odum N, Bonefeld CM, Geisler C. Scientific reports. 2012 2:266.
[PubMed:22355778]
[PMC:PMC3278673]
6
Extracellular human immunodeficiency virus type 1 viral protein R causes reductions in astrocytic ATP and glutathione levels compromising the antioxidant reservoir. Ferrucci A, Nonnemacher MR, Cohen EA, Wigdahl B. Virus research. 2012 167:358-69. (ICC; Human)
[PubMed:22691542]
[PMC:PMC3398186]
7
Exploratory clinical trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for imaging xC- transporter using positron emission tomography in patients with non-small cell lung or breast cancer. Baek S, Choi CM, Ahn SH, Lee JW, Gong G, Ryu JS, Oh SJ, Bacher-Stier C, Fels L, Koglin N, Hultsch C, Schatz CA, Dinkelborg LM, Mittra ES, Gambhir SS, Moon DH. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012 18:5427-37. (IHC; Human)
[PubMed:22893629]
8
Early intraarticular injection of hyaluronic acid attenuates osteoarthritis progression in anterior cruciate ligament-transected rats. Tsai WY, Wu JL, Liu CC, Cherng CH, Tsai RY, Jean YH, Wong CS. Connective tissue research. 2013 54:49-54. (WB; Human)
[PubMed:23020698]
9
The pharmacologic inhibition of the xc- antioxidant system improves the antitumor efficacy of COX inhibitors in the in vivo model of 3-MCA tumorigenesis. Balza E, Castellani P, Delfino L, Truini M, Rubartelli A. Carcinogenesis. 2013 34:620-6.
[PubMed:23161574]
10
(4S)-4-(3-18F-fluoropropyl)-L-glutamate for imaging of xC transporter activity in hepatocellular carcinoma using PET: preclinical and exploratory clinical studies. Baek S, Mueller A, Lim YS, Lee HC, Lee YJ, Gong G, Kim JS, Ryu JS, Oh SJ, Lee SJ, Bacher-Stier C, Fels L, Koglin N, Schatz CA, Dinkelborg LM, Moon DH. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2013 54:117-23.
[PubMed:23232273]
11
A functional microRNA library screen reveals miR-410 as a novel anti-apoptotic regulator of cholangiocarcinoma. Palumbo T, Poultsides GA, Kouraklis G, Liakakos T, Drakaki A, Peros G, Hatziapostolou M, Iliopoulos D. BMC cancer. 2016 16:353. (WB; Mouse)[Full Text Article]
[PubMed:27259577]
[PMC:PMC4893280]
12
Increased Expression of System xc- in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance. Polewski MD, Reveron-Thornton RF, Cherryholmes GA, Marinov GK, Cassady K, Aboody KS. Molecular cancer research : MCR. 2016 December;14:1229-1242. (Human)[Full Text Article]
[PubMed:27658422]
[PMC:PMC6237285]
Related Antibodies: LS-B4345.
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PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).
