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SMAD3

SMAD family member 3

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Gene Name: SMAD family member 3
Synonyms: SMAD3, HSPC193, HMAD-3, HsT17436, LDS1C, LDS3, Mad homolog JV15-2, MAD3, MADH3, Mothers against DPP homolog 3, JV15-2, SMA- and MAD-related protein 3, SMAD family member 3, MAD homolog 3, HSMAD3, Mad protein homolog, SMAD 3
Target Sequences: NM_005902 NP_005893.1 P84022

Publications (4)

1
Zinc supplementation attenuates ethanol- and acetaldehyde-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS) production and by influencing intracellular signaling. Szuster-Ciesielska A, Plewka K, Daniluk J, Kandefer-Szersze M. Biochemical pharmacology. 2009 78:301-14. (WB) [PubMed:19376089]
2
Characterization of articular cartilage homeostasis and the mechanism of superior cartilage regeneration of MRL/MpJ mice. Zhenhan Deng, Xueqin Gao, Xuying Sun, Sarah Amra, Aiping Lu, Yan Cui, Holger K Eltzschig, Guanghua Lei, Johnny Huard. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 Aug;33:8809-8821. [Full Text Article] [PubMed:31042406] Related Antibodies: LS-B64.
3
YAP and TAZ are required for the postnatal development and the maintenance of the structural integrity of the oviduct. Philippe Godin , Mayra Tsoi , Marilène Paquet , Derek Boerboom. Reproduction (Cambridge, England). 2020 Aug;;160:307-318. [Full Text Article] [PubMed:32520726] Related Antibodies: LS-B64.
4
Carvedilol ameliorates dexamethasone-induced myocardial injury in rats independent of its action on the a1-adrenergic receptor. Rasha M S M Mohamed, Enssaf Ahmad Ahmad, Bothina H F Omran, Amr T Sakr, Islam A A E-H Ibrahim, Mona F Mahmoud, Mostafa E El-Naggar. Naunyn-Schmiedeberg's archives of pharmacology. 2022 December;395:1537-1548. [Full Text Article] [PubMed:36085425] [PMC:PMC9630193]
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96-Well Microplate
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Colorimetric - 450nm (TMB)
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12 x 8-Well Microstrips
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
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0.156 - 10 ng/ml
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Colorimetric - 450nm (TMB)
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0.625 - 40 ng/ml
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0.625 - 40 ng/ml
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96-Well Strip Plate
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0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
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96-Well Strip Plate
Rabbit
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
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0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
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0.625 - 40 ng/ml
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0.156 - 10 ng/ml
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0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
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0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).