SMARCB1 / INI1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1

Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.

☰ Filters

Products

Proteins (11)

Type

Over-Expression Lysate (4)

Recombinant (7)

Target

SMARCB1 / INI1 (11)

Publications

No (11)

Tag

6His, N-terminus (3)

GST (1)

GST, N-terminus (1)

His-SUMO (1)

Myc-DDK (Flag) (5)

Species

Human (9)

Source

293T Cells (2)

Baculovirus (1)

E. coli (2)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (3)

Select

Human SMARCB1 / INI1 Protein (Recombinant 6His, N-terminus) (aa2-376) - LS-G23393

Source:

Yeast

Tag:

6His, N-terminus

Molecular Weight:

45 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

Select

Human SMARCB1 / INI1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67408

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43 kDa

Price:

20 µg/$1,107

Select

Human SMARCB1 / INI1 Protein (Recombinant GST, N-terminus) (aa81-180) - LS-G60142

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human SMARCB1 / INI1 Protein (Recombinant His-SUMO) (Full Length) - LS-G21691

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

59 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

Select

Human SMARCB1 / INI1 Protein (Recombinant GST) (Full Length) - LS-G30457

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

70.5 kDa

Price:

2 µg/$439

Select

SMARCB1 / INI1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99956

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44 kDa

Price:

100 µg/$494

Select

Human SMARCB1 / INI1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79775

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44 kDa

Price:

20 µg/$150

Select

Human SMARCB1 / INI1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79776

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43 kDa

Price:

20 µg/$150

Select

SMARCB1 / INI1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121992

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43 kDa

Price:

100 µg/$494

Select

Human SMARCB1 / INI1 Protein (Recombinant 6His, N-terminus) - LS-G137450

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

49.0 kDa

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

Select

Human SMARCB1 / INI1 Protein (Recombinant 6His, N-terminus) (aa2-376) - LS-G55975

Source:

Baculovirus

Tag:

6His, N-terminus

Price:

100 µg/$1,164; 20 µg/$475; 1 mg/$2,187

Viewing 1-11 of 11 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.