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SMMHC / MYH11

Myosin, Heavy Chain 11, Smooth Muscle

SMMHC / MYH11 is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene Name: Myosin, Heavy Chain 11, Smooth Muscle
Synonyms: MYH11, AAT4, FAA4, KIAA0866, Myosin-11, Myosin heavy chain 11, SMHC, SMMHC
Target Sequences: NM_002474 NP_002465.1 P35749

Publications (2)

1
Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation. Jiang Y, Luo Y, Tang Y, Moats R, Warburton D, Zhou S, Lou J, Pryhuber GS, Shi W, Wang LL. Scientific reports. 2019 March;9:5296. [Full Text Article] [PubMed:30923323] [PMC:PMC6439218]
2
A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra. Gervaise H Henry, Alicia Malewska, Diya B Joseph, Venkat S Malladi, Jeon Lee, Jose Torrealba, Ryan J Mauck, Jeffrey C Gahan, Ganesh V Raj, Claus G Roehrborn, Gary C Hon, Malcolm P MacConmara, Jeffrey C Reese, Ryan C Hutchinson, Chad M Vezina, Douglas W Strand. Cell reports. 2018 Dec;25:3530-3542e5. [Full Text Article] [PubMed:30566875] [PMC:PMC6411034] Related Antibodies: LS-C390741.

☰ Filters
Antibodies (51)
ELISA Kits (7)
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Custom (5)
Over-Expression Lysate (2)
Primary (51)
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SMMHC / MYH11 (62)
Human (46)
Mouse (6)
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rabbit (32)
mouse (19)
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IgG1,k (11)
monoclonal mc (19)
polyclonal pc (30)
recombinant monoclonal rmc (2)
ID8 (3)
MYH11/2303R (2)
MYH11/923 (3)
MYH11/923 + SMMS-1 (3)
SMM11-1 (3)
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Human (2)
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E. coli (2)
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SMMHC / MYH11 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
SMMHC / MYH11 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC-P, WB
Unconjugated
50 µl/$460
SMMHC / MYH11 Antibody - Formalin-fixed, paraffin-embedded human colon carcinoma stained with SMMHC antibody (MYH11/923).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (MYH11/923) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
SMMHC / MYH11 Antibody - Formalin-fixed, paraffin-embedded human colon carcinoma stained with SMMHC antibody (MYH11/923).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (Ready-to-Use) (MYH11/923) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
SMMHC / MYH11 Antibody - Formalin-fixed, paraffin-embedded human colon carcinoma stained with SMMHC antibody (MYH11/923).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (MYH11/923) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
SMMHC / MYH11 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
SMMHC / MYH11 Rabbit anti-Rat Polyclonal (aa211-482) Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$460
SMMHC / MYH11 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
SMMHC / MYH11 Rabbit anti-Human Recombinant Monoclonal (MYH11/2303R) Antibody
Human
IHC-P
Unconjugated
100 µg/$525
SMMHC / MYH11 Antibody - Formalin-fixed, paraffin-embedded human Leiomyosarcoma stained with SMMHC antibody (MYH11/923 + SMMS-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (MYH11/923 + SMMS-1) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
SMMHC / MYH11 Antibody - Formalin-fixed, paraffin-embedded human Leiomyosarcoma stained with SMMHC antibody (MYH11/923 + SMMS-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (Ready-to-Use) (MYH11/923 + SMMS-1) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
SMMHC / MYH11 Antibody - Formalin-fixed, paraffin-embedded human Leiomyosarcoma stained with SMMHC antibody (MYH11/923 + SMMS-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (MYH11/923 + SMMS-1) Antibody
Rat, Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
SMMHC / MYH11 Antibody - Formalin-fixed, paraffin-embedded human angiosarcoma stained with SM-MHC antibody (SPM201).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (SPM201) Antibody
Chicken, Bovine, Rabbit, Dog, Guinea pig, Rat, Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
SMMHC / MYH11 Antibody - Formalin-fixed, paraffin-embedded human angiosarcoma stained with SM-MHC antibody (SPM201).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SPM201) Antibody
Chicken, Bovine, Rabbit, Dog, Guinea pig, Rat, Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
SMMHC / MYH11 Antibody - Formalin-fixed, paraffin-embedded human Leiomyosarcoma stained with SM-MHC antibody (SMMS-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (SMMS-1) Antibody
Chicken, Bovine, Rabbit, Dog, Guinea pig, Rat, Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
SMMHC / MYH11 Antibody - Formalin-fixed, paraffin-embedded human Leiomyosarcoma stained with SM-MHC antibody (SMMS-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SMMS-1) Antibody
Chicken, Bovine, Rabbit, Dog, Guinea pig, Rat, Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
SMMHC / MYH11 Antibody - Formalin-fixed, paraffin-embedded human Leiomyosarcoma stained with SM-MHC antibody (SMMS-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (Ready-to-Use) (SMMS-1) Antibody
Chicken, Bovine, Rabbit, Dog, Guinea pig, Rat, Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
SMMHC / MYH11 Antibody - Formalin-fixed, paraffin-embedded human Leiomyosarcoma stained with SM-MHC antibody (ID8).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (ID8) Antibody
Chicken, Bovine, Rabbit, Dog, Guinea pig, Rat, Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
SMMHC / MYH11 Antibody - Formalin-fixed, paraffin-embedded human Leiomyosarcoma stained with SM-MHC antibody (ID8).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (Ready-to-Use) (ID8) Antibody
Chicken, Bovine, Rabbit, Dog, Guinea pig, Rat, Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
SMMHC / MYH11 Antibody - Formalin-fixed, paraffin-embedded human Leiomyosarcoma stained with SM-MHC antibody (ID8).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (ID8) Antibody
Chicken, Bovine, Rabbit, Dog, Guinea pig, Rat, Pig, Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
SMMHC / MYH11 Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
SMMHC / MYH11 Rabbit anti-Human Polyclonal Antibody
Pig, Human
IHC-P, WB
Unconjugated
50 µl/$460
SMMHC / MYH11 Antibody - IHC testing of FFPE human Leiomyosarcoma with SMMHC antibody (clone SMM11-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (SMM11-1) Antibody
Rat, Human
IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
SMMHC / MYH11 Antibody - IHC testing of FFPE human Leiomyosarcoma with SMMHC antibody (clone SMM11-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (Ready-to-Use) (SMM11-1) Antibody
Rat, Human
IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
SMMHC / MYH11 Antibody - IHC testing of FFPE human Leiomyosarcoma with SMMHC antibody (clone SMM11-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SMM11-1) Antibody
Rat, Human
IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
SMMHC / MYH11 Antibody - Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Select
SMMHC / MYH11 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
SMMHC / MYH11 Antibody - Immunofluorescence staining of MYH11 in U2OS cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human MYH11 polyclonal antibody (dilution ratio 1:200) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Nucleus.
Select
SMMHC / MYH11 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF
Unconjugated
100 µl/$412
Select
SMMHC / MYH11 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$351
Select
SMMHC / MYH11 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$412
Viewing 1-25 of 62 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).