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SOX2

SRY (sex determining region Y)-box 2

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation.

Gene Name: SRY (sex determining region Y)-box 2
Family/Subfamily: Transcription factor
Synonyms: SOX2, MCOPS3, Transcription factor SOX2, ANOP3, Transcription factor SOX-2, SRY-related HMG-box gene 2
Target Sequences: L07335 AAA35997.1 P48431

Publications (8)

1
Developmental changes in the expression of sox2 in the zebrafish brain. Carlisle FA, Steel KP, Lewis MA. Microscopy research and technique. 2010 (WB; Zebrafish) [PubMed:20734413] Related Antibodies: LS-C31802.
2
Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2. Domyan ET, Ferretti E, Throckmorton K, Mishina Y, Nicolis SK, Sun X. Development (Cambridge, England). 2011 138:971-81. (ICC, IHC; Mouse) [PubMed:21303850]
3
Distinct functions of Sox2 control self-renewal and differentiation in the osteoblast lineage. Seo E, Basu-Roy U, Zavadil J, Basilico C, Mansukhani A. Molecular and cellular biology. 2011 31:4593-608. [PubMed:21930787] [PMC:PMC3209254]
4
Connexin 43 reverses malignant phenotypes of glioma stem cells by modulating E-cadherin. Yu SC, Xiao HL, Jiang XF, Wang QL, Li Y, Yang XJ, Ping YF, Duan JJ, Jiang JY, Ye XZ, Xu SL, Xin YH, Yao XH, Chen JH, Chu WH, Sun W, Wang B, Wang JM, Zhang X, Bian XW. Stem cells (Dayton, Ohio). 2012 30:108-20. [PubMed:22131169]
5
Effects of Cryopreservation on Canine Multipotent Stromal Cells from Subcutaneous and Infrapatellar Adipose Tissue. Duan W, Lopez MJ. Stem cell reviews. 2016 12:257-68. (ICC, Flo; Canine) [Full Text Article] [PubMed:26537238] [PMC:PMC4841859] Related Antibodies: LS-B4562.
6
MELK inhibition targets cancer stem cells through downregulation of SOX2 expression in head and neck cancer cells. Lili Ren, Boya Deng, Vassiliki Saloura, Jae-Hyun Park, Yusuke Nakamura. Oncology reports. 2019 Apr;41:2540-2548. [Full Text Article] [PubMed:30720113]
7
Tumour angiogenesis normalized by myo-inositol trispyrophosphate alleviates hypoxia in the microenvironment and promotes antitumor immune response. Bouchra El Hafny-Rahbi, Klaudia Brodaczewska, Guillaume Collet, Aleksandra Majewska , Krzysztof Klimkiewicz , Anthony Delalande, Catherine Grillon, Claudine Kieda. Journal of cellular and molecular medicine. 2021 Apr;;25:3284-3299. [Full Text Article] [PubMed:33624446] [PMC:PMC8034441] Related Antibodies: LS-C108535.
8
Sox-2 in taste bud and lateral line system of zebrafish during development. German[Character e0] A, Montalbano G, Guerrera MC, Laura R, Levanti M, Abbate F, de Carlos F, Vega JA, Ciriaco E. Neuroscience letters. 2009 Dec;467:36-9. [Full Text Article] [PubMed:19800392] Related Antibodies: LS-C31802.
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Products
ELISA Kits (16)
Competitive EIA (2)
Custom (2)
Sandwich (12)
SOX2 (16)
Human (4)
Mouse (2)
Rat (4)
Chicken (2)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
96-Well Microplate (1)
96-Well Strip Plate (15)
No (16)
Cell Lysates (1)
Plasma (8)
Serum (8)
Tissue Homogenates (3)
SOX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
SOX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
SOX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
SOX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$715
SOX2 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
SOX2 ELISA Kit
Select
Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$783
SOX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SOX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
SOX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
SOX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
SOX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
SOX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
SOX2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
SOX2 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
SOX2 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Rat
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
SOX2 ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Mouse
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).