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Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin.
Gene Name: | serine peptidase inhibitor, Kazal type 5 |
Synonyms: | SPINK5, NETS, LETKI, VAKTI, LEKTI |
Target Sequences: | NM_006846 NP_006837.2 Q9NQ38 |
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