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SPP1 / Osteopontin
secreted phosphoprotein 1
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
| Gene Name: | secreted phosphoprotein 1 |
| Synonyms: | SPP1, BSPI, BNSP, Bone sialoprotein 1, ETA-1, Nephropontin, OPN, Secreted phosphoprotein 1, SPP-1, SPP1/CALPHA1 fusion, Urinary stone protein, Uropontin, Osteopontin, Bone sialoprotein I |
| Target Sequences: | NM_000582 NP_000573.1 P10451 |
Publications (8)
1
Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences. Kon S, Yokosaki Y, Maeda M, Segawa T, Horikoshi Y, Tsukagoshi H, Rashid MM, Morimoto J, Inobe M, Shijubo N, Chambers AF, Uede T. Journal of cellular biochemistry. 2002 84:420-32.
[PubMed:11787071]
2
Osteopontin induces beta-catenin signaling through activation of Akt in prostate cancer cells. Robertson BW, Chellaiah MA. Experimental cell research. 2010 316:11-Jan.
[PubMed:19850036]
[PMC:PMC2787770]
Related Antibodies: LS-B425.
3
Expression of chondro-osteogenic BMPs in clinical samples of patellar tendinopathy. Rui YF, Lui PP, Rolf CG, Wong YM, Lee YW, Chan KM. Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA. 2012 20:1409-17. (IHC; Human)
[PubMed:21946950]
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(32)
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(1)
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(21)
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(14)
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(1)
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(46)
Serum
(46)
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(23)
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(5)
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
Sandwich
96-Well Strip Plate
Bovine
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$889
Sandwich
96-Well Microplate
Pig
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Sandwich CLIA
96-Well Strip Plate
Mouse
6.86 - 5000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$871
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$582
Sandwich
96-Well Microplate
Human
50 - 18000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
Sandwich
96-Well Strip Plate
Mouse
39 - 2500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$610
Sandwich
96-Well Microplate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Sandwich
96-Well Microplate
Mouse
2.743 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
Sandwich
96-Well Strip Plate
Rhesus monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$826
Sandwich
96-Well Strip Plate
Pig
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$779
Sandwich
96-Well Microplate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$734
Sandwich CLIA
12 x 8-Well Microstrips
Human
62.5 - 4000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Sandwich
12 x 8-Well Microstrips
Human
63 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$534
Sandwich
96-Well Strip Plate
Rat
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
Sandwich
96-Well Strip Plate
Rabbit
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$715
Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$573
Sandwich
96-Well Microplate
Mouse
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$699
Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Breast Milk, Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$699
Sandwich
96-Well Strip Plate
Dog
3.13 - 200 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$748
Sandwich
96-Well Strip Plate
Dog
3.12 - 200 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$811
Development Kit
Antibody Pair and Standard
Mouse
62.4 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,005; 1000 Wells/$1,451
Development Kit
Antibody Pair and Standard
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,254; 1000 Wells/$1,867
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