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SSTR5

somatostatin receptor 5

Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.

Gene Name: somatostatin receptor 5
Family/Subfamily: GPCR , Somatostatin
Synonyms: SSTR5, Somatostatin receptor 5, SS5-R, SS5R, Somatostatin receptor type 5, Sst5, SS-5-R
Target Sequences: NM_001053 NP_001044.1 P35346

Publications (1)

1
Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: a proposal of scoring system correlated with somatostatin receptor scintigraphy. Volante M, Brizzi MP, Faggiano A, La Rosa S, Rapa I, Ferrero A, Mansueto G, Righi L, Garancini S, Capella C, De Rosa G, Dogliotti L, Colao A, Papotti M. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2007 20:1172-82. (IHC-P; Human) [PubMed:17873898] Related Antibodies: LS-A2639.

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SSTR5 Protein - 12.5% SDS-PAGE of human SSTR5 stained with Coomassie Blue
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Wheat Germ Extract
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66.99 kDa
2 µg/$439
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).