STAT1

signal transducer and activator of transcription 1, 91kDa

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.

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Products

ELISA Kits (20)

Type

Cell-Based (1)

Cell-Based Phosphorylation (3)

Custom (3)

DNA Binding (1)

DNA Binding Phosphorylation (2)

Sandwich (10)

Target

STAT1 (20)

Reactivity

Human (11)

Mouse (10)

Rat (6)

Chicken (1)

Guinea pig (1)

Monkey (1)

Pig (1)

Porcine (1)

Rabbit (1)

Format

12 x 8-Well Microstrips (4)

96-Well Microplate (4)

96-Well Strip Plate (12)

Publications

No (20)

Sample Type

Adherent Cell Cultures (4)

Cell Lysates (4)

Nuclear Lysates (3)

Plasma (4)

Serum (4)

Tissue Homogenates (3)

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Human STAT1 (Sandwich ELISA) ELISA Kit - LS-F39604

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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Mouse/Human/Rat STAT1 (DNA-Binding ELISA) ELISA Kit - LS-F803

Type:

DNA Binding

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$662

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Mouse/Human/Rat Phospho-STAT1 (Ser727) (DNA-Binding Phosphorylation ELISA) ELISA Kit - LS-F914

Type:

DNA Binding Phosphorylation

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$735

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Mouse/Human/Rat Phospho-STAT1 (Tyr701) (DNA-Binding Phosphorylation ELISA) ELISA Kit - LS-F924

Type:

DNA Binding Phosphorylation

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$735

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Human STAT1 (Sandwich ELISA) ELISA Kit - LS-F35708

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse/Human/Rat Phospho-STAT1 (Ser727) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1622

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse STAT1 (Sandwich ELISA) ELISA Kit - LS-F35710

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Rabbit STAT1 (Sandwich ELISA) ELISA Kit - LS-F48037

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Porcine STAT1 (Sandwich ELISA) ELISA Kit - LS-F48036

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Chicken STAT1 (Sandwich ELISA) ELISA Kit - LS-F48033

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Guinea pig STAT1 (Sandwich ELISA) ELISA Kit - LS-F48034

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Guinea pig

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Monkey STAT1 (Sandwich ELISA) ELISA Kit - LS-F48035

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

Select

Pig STAT1 (Custom ELISA) ELISA Kit - LS-F18409

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Mouse STAT1 (Custom ELISA) ELISA Kit - LS-F18408

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Human STAT1 (Custom ELISA) ELISA Kit - LS-F18410

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Mouse/Human/Rat STAT1 (Cell-Based ELISA) ELISA Kit - LS-F2326

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

Select

Mouse STAT1 (Sandwich ELISA) ELISA Kit - LS-F38415

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Human STAT1 (Sandwich ELISA) ELISA Kit - LS-F38036

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

Select

Mouse/Human/Rat Phospho-STAT1 (Tyr701) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1623

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

Select

Mouse/Human Phospho-STAT1 (Tyr701) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F948

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$556

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