STAT3

signal transducer and activator of transcription 3 (acute-phase response factor)

STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

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Products

Antibodies (232)

Proteins (21)

ELISA Kits (20)

Type

Cell-Based (1)

Cell-Based Phosphorylation (3)

Custom (3)

Development Kit (1)

DNA Binding (1)

Over-Expression Lysate (4)

Primary (232)

Recombinant (17)

Sandwich (10)

Sandwich CLIA (1)

Target

STAT3 (273)

Reactivity

Human (218)

Mouse (142)

Rat (134)

Bat (10)

Bovine (33)

Carp (1)

Chicken (13)

Chimpanzee (9)

Cow (8)

Dog (16)

Gibbon (9)

Goat (1)

Guinea pig (7)

Hamster (3)

Horse (11)

Monkey (19)

Non-Human Primate (1)

Orangutan (9)

Pig (17)

Rabbit (11)

Sheep (4)

Xenopus (6)

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IHC (83)

IHC-P (32)

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DB (4)

ELISA (69)

GS (3)

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IP (41)

Peptide-ELISA (8)

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rabbit (202)

mouse (29)

goat (1)

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DevKit DuoPlus (1)

IHCPlus (6)

Isotype

Ig (1)

IgG (118)

IgG1 (13)

IgG1,k (1)

IgG2a (2)

IgG2a,k (1)

IgG2b (2)

IgG2b,k (1)

Clonality

monoclonal mc (31)

polyclonal pc (199)

recombinant monoclonal rmc (2)

Clone

1200CT146.104.153 (1)

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4E3 (1)

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OTI21E7 (2)

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12 x 8-Well Microstrips (2)

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PE Conjugated (14)

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Unconjugated (135)

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Epitope

pTyr705 (26)

pSer727 (22)

C-Terminus (14)

aa563-670 (8)

aa656-768 (8)

aa673-699 (7)

pTyr68 (6)

N-Terminus (4)

aa683-732 (4)

aa135-279 (3)

640-720 aa (2)

Asym-Me2-Arg31 (2)

670-750 aa (1)

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Acetyl-Lys87 (1)

Internal Region (1)

Pro699 (1)

Ser691 (1)

Ser727 (1)

Thr721 (1)

aa139-167 (1)

aa154-175 (1)

aa335-546 (1)

aa4-31 (1)

aa51-278 (1)

aa576-678 (1)

aa656-705 (1)

aa672-721 (1)

aa675-725 (1)

aa683-709 (1)

aa688-722 (1)

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Publications

No (270)

Yes (3)

Sample Type

Adherent Cell Cultures (4)

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Nuclear Lysates (1)

Plasma (8)

Serum (9)

Tissue Homogenates (4)

Tag

6His, C-terminus (2)

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GST (1)

GST, N-terminus (1)

His (4)

His, N-Terminal (3)

His-GST (2)

His-SUMO (1)

Myc-DDK (Flag) (6)

Species

All species (4)

Bovine (1)

Human (13)

Rat (1)

Source

293T Cells (2)

E. coli (12)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (3)

Select

STAT3 Antibody (aa683-732) LS-B4693

(4.1) Rating

(2) Publication(s)

Antibody:

STAT3 Rabbit anti-Human Polyclonal (aa683-732) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ STAT3 Antibody (clone 7G3H4) LS-B4102

(4.0) Rating

Antibody:

STAT3 Mouse anti-Human Monoclonal (7G3H4) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

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STAT3 Antibody LS-C76017

Antibody:

STAT3 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, Flo, ICC, IP, WB

Format:

Unconjugated

Price:

50 µg/$558

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STAT3 Antibody (phospho-Tyr705) LS-C354108

Antibody:

STAT3 Rabbit anti-Human Polyclonal (pTyr705) Antibody

Reactivity:

Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Pig, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$315

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STAT3 Antibody (Acetyl-Lys87) LS-C413302

Antibody:

STAT3 Rabbit anti-Human Polyclonal (Acetyl-Lys87) Antibody

Reactivity:

Chicken, Bovine, Rat, Pig, Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$341

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STAT3 Antibody (phospho-Ser727) LS-C352904

(4.0) Rating

(1) Publication(s)

Antibody:

STAT3 Rabbit anti-Human Polyclonal (pSer727) Antibody

Reactivity:

Chicken, Bovine, Mouse, Dog, Rat, Pig, Human, Monkey

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$315

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IHC-plus™ STAT3 Antibody (C-Terminus) LS-B9434

(4.0) Rating

Antibody:

STAT3 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$460

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STAT3 Antibody (phospho-Ser727) LS-C177954

Antibody:

STAT3 Rabbit anti-Human Polyclonal (pSer727) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$328; 100 µl/$419

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STAT3 Antibody (phospho-Tyr705) LS-C96979

Antibody:

STAT3 Rabbit anti-Human Polyclonal (pTyr705) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Mouse/Human/Rat Phospho-STAT3 (Ser727) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1624

(4.0) Rating

(1) Publication(s)

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat Phospho-STAT3 (Tyr705) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1625

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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IHC-plus™ STAT3 Antibody (Internal Region) LS-B11150

(4.0) Rating

Antibody:

STAT3 Goat anti-Human Polyclonal (Internal Region) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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STAT3 Antibody (C-Terminus) LS-C352900

Antibody:

STAT3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Chicken, Bovine, Mouse, Dog, Rat, Pig, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$299

Select

STAT3 Antibody (phospho-Tyr705, clone PS3/1) LS-C179385

Antibody:

STAT3 Mouse anti-Human Monoclonal (pTyr705) (PS3/1) Antibody

Reactivity:

Zebrafish

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$403

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Human STAT3 (Sandwich ELISA) ELISA Kit - LS-F54989

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$730

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STAT3 Antibody (phospho-Tyr705, clone 7H65) LS-C182749

Antibody:

STAT3 Rabbit anti-Mouse Monoclonal (pTyr705) (7H65) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ICC, IHC, IP, WB

Format:

Unconjugated

Price:

100 µl/$748

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STAT3 Antibody (APC, Cy7) LS-C733289

Antibody:

STAT3 Rabbit anti-Human Polyclonal (APC, Cy7) Antibody

Reactivity:

Mouse, Bovine, Rat, Human

Applications:

ICC, IP, WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$497; 200 µl/$632; 500 µl/$1,132; 1 ml/$1,369; 2 ml/$1,916; 5 ml/$3,592

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IHC-plus™ STAT3 Antibody LS-B10075

(4.0) Rating

Antibody:

STAT3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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STAT3 Antibody (C-Terminus, Magnetic beads) LS-C171872

Antibody:

STAT3 Rabbit anti-Human Polyclonal (C-Terminus) (Magnetic beads) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IP

Format:

Magnetic beads Conjugated

Price:

100 µg/$399

Select

STAT3 Antibody (phospho-Tyr705) LS-C10385

Antibody:

STAT3 Rabbit anti-Mouse Polyclonal (pTyr705) Antibody

Reactivity:

Chicken, Mouse, Rat, Human

Applications:

ELISA, ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$717

Select

Human STAT3 (Sandwich ELISA) ELISA Kit - LS-F27241

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1 - 25 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$805

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Human STAT3 Protein (Recombinant 6His, N-terminus) (aa1-770) - LS-G57262

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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STAT3 Antibody (phospho-Tyr705) LS-C177955

Antibody:

STAT3 Rabbit anti-Human Polyclonal (pTyr705) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$328; 100 µl/$419

Select

STAT3 Antibody (phospho-Tyr705) LS-C10389

Antibody:

STAT3 Mouse anti-Mouse Monoclonal (pTyr705) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, IP, WB

Format:

Unconjugated

Price:

100 µl/$618

Select

STAT3 Antibody (phospho-Tyr705) LS-C335765

Antibody:

STAT3 Rabbit anti-Human Polyclonal (pTyr705) Antibody

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$287; 100 µl/$431

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