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TACR3 / NK3R

tachykinin receptor 3

This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.

Gene Name: tachykinin receptor 3
Family/Subfamily: GPCR , Tachykinin
Synonyms: TACR3, HH11, Nmk-r, NK3R, NKR, Tachykinin receptor 3, Neurokinin B, Neurokinin B receptor, NK-3 receptor, NK-3R, TAC3R, Neurokinin 3 receptor, Neurokinin beta receptor, Neuromedin-K receptor, TAC3RL
Target Sequences: NM_001059 NP_001050.1 P29371

Publications (10)

1
Localisation of tachykinin NK1 and NK3 receptors in the human prefrontal and visual cortex. Tooney PA, Au GG, Chahl LA. Neuroscience letters. 2000 283:185-8. (IHC; Human) [PubMed:10754218]
2
Localization of NK1 and NK3 receptors in guinea-pig brain. Yip J, Chahl LA. Regulatory peptides. 2001 98:55-62. [PubMed:11179779]
3
The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina. Dick O, tom Dieck S, Altrock WD, Ammermller J, Weiler R, Garner CC, Gundelfinger ED, Brandsttter JH. Neuron. 2003 37:775-86. [PubMed:12628168]
4
Expression of connexin36 in cone pedicles and OFF-cone bipolar cells of the mouse retina. Feigenspan A, Janssen-Bienhold U, Hormuzdi S, Monyer H, Degen J, Shl G, Willecke K, Ammermller J, Weiler R. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 24:3325-34. [PubMed:15056712]
5
Agonist and hypertonic saline-induced trafficking of the NK3-receptors on vasopressin neurons within the paraventricular nucleus of the hypothalamus. Haley GE, Flynn FW. American journal of physiology. Regulatory, integrative and comparative physiology. 2006 290:R1242-50. [PubMed:16357093]
6
Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: Morphologic evidence of interrelated function within the arcuate nucleus. Burke MC, Letts PA, Krajewski SJ, Rance NE. The Journal of comparative neurology. 2006 498:712-26. [PubMed:16917850]
7
Transformation of cone precursors to functional rod photoreceptors by bZIP transcription factor NRL. Oh EC, Khan N, Novelli E, Khanna H, Strettoi E, Swaroop A. Proceedings of the National Academy of Sciences of the United States of America. 2007 104:1679-84. (ICC; Mouse) [PubMed:17242361] [PMC:PMC1780067]
8
Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat. Krajewski SJ, Burke MC, Anderson MJ, McMullen NT, Rance NE. Neuroscience. 2010 166:680-97. (ICC, IHC; Rat) [PubMed:20038444] [PMC:PMC2823949]
9
Immunofluorescent histochemical and ultrastructural studies on the innervation of kisspeptin/neurokinin B neurons to tuberoinfundibular dopaminergic neurons in the arcuate nucleus of rats. Sawai N, Iijima N, Takumi K, Matsumoto K, Ozawa H. Neuroscience research. 2012 74:6-Oct. (ICC, IHC; Rat) [PubMed:22691459]
10
Neurokinin 3 receptor forms a complex with acetylated histone H3 and H4 in hypothalamic neurons following hyperosmotic challenge. Flynn FW, Jensen DD, Thakar A, Xu X, Flynn SW, Zhang Z. American journal of physiology. Regulatory, integrative and comparative physiology. 2011 Sep;301:R822-31. [Full Text Article] [PubMed:21697521] [PMC:PMC3174760] Related Antibodies: LS-C73388.
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Antibodies (34)
Primary (34)
TACR3 / NK3R (34)
Human (32)
Mouse (15)
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rabbit (33)
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aa406-435 (7)
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TACR3 / NK3R Antibody - Anti-TACR3 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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TACR3 / NK3R Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
TACR3 / NK3R Antibody - Anti-TACR3 antibody IHC of human brain, hippocampus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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TACR3 / NK3R Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
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TACR3 / NK3R Rabbit anti-Rat Polyclonal (aa441-450) Antibody
Mouse, Dog, Bovine, Rat, Hamster, Pig, Bat, Human, Monkey
WB
Unconjugated
100 µl/$688
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TACR3 / NK3R Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Guinea pig, Rat
IHC, IHC-Fr
Unconjugated
150 µl/$649
TACR3 / NK3R Antibody - Anti-TACR3 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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TACR3 / NK3R Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
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TACR3 / NK3R Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
0.1 mg/$518
TACR3 / NK3R Antibody - Immunofluorescence analysis of A549 cells, using NK3R Antibody. The picture on the right is blocked with the synthesized peptide.
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TACR3 / NK3R Rabbit anti-Human Polyclonal (aa401-450) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
TACR3 / NK3R Antibody - Immunohistochemistry of NK3R in human brain tissue with NK3R antibody at 5 ug/ml.
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TACR3 / NK3R Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
TACR3 / NK3R Antibody - Immunohistochemistry of paraffin-embedded human brain using antibody at 1:100 dilution.
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TACR3 / NK3R Rabbit anti-Human Polyclonal (aa356-465) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
TACR3 / NK3R Antibody - Western blot of NK-3R antibody
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TACR3 / NK3R Rabbit anti-Human Polyclonal (370-450 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TACR3 / NK3R Antibody - Staining COLO205 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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TACR3 / NK3R Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TACR3 / NK3R Antibody - Western blot of NK-3R (P434) pAb in extracts from COLO205 cells.
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TACR3 / NK3R Rabbit anti-Human Polyclonal (Pro434) Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µl/$321; 100 µl/$403
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TACR3 / NK3R Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TACR3 / NK3R Antibody - Immunohistochemistry of paraffin-embedded human stomach cancer tissue.
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TACR3 / NK3R Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
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TACR3 / NK3R Rabbit-New Zealand White anti-Human Polyclonal (aa400-450) Antibody
Human
IHC, WB
Unconjugated
100 µl/$393
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TACR3 / NK3R Rabbit anti-Human Polyclonal (aa406-435) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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TACR3 / NK3R Rabbit anti-Human Polyclonal (aa406-435) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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TACR3 / NK3R Rabbit anti-Human Polyclonal (aa406-435) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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TACR3 / NK3R Rabbit anti-Human Polyclonal (aa406-435) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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TACR3 / NK3R Rabbit anti-Human Polyclonal (aa406-435) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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TACR3 / NK3R Rabbit anti-Human Polyclonal (HRP) Antibody
Mouse, Human
IHC, WB
HRP Conjugated
100 µl/$1,006
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TACR3 / NK3R Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Human
IHC, WB
Biotin Conjugated
100 µl/$1,006
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TACR3 / NK3R Rabbit anti-Human Polyclonal (FITC) Antibody
Mouse, Human
IHC, WB
FITC Conjugated
100 µl/$1,006
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TACR3 / NK3R Rabbit anti-Human Polyclonal (PE) Antibody
Mouse, Human
IHC, WB
PE Conjugated
100 µl/$1,006
TACR3 / NK3R Antibody - Western blot analysis of the lysates from HepG2 cells using NK3R antibody.
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TACR3 / NK3R Rabbit anti-Human Polyclonal (aa385-434) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).