TCF7L2 / TCG4

transcription factor 7-like 2 (T-cell specific, HMG-box)

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.

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Products

Proteins (17)

Type

Over-Expression Lysate (14)

Recombinant (3)

Target

TCF7L2 / TCG4 (17)

Publications

No (17)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (14)

Species

Human (10)

Source

293T Cells (7)

E. coli (1)

HEK 293 Cells (7)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human TCF7L2 / TCG4 Protein (Recombinant 6His, N-terminus) (aa1-456) - LS-G56990

Source:

E. coli

Tag:

6His, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human TCF7L2 / TCG4 Protein (Recombinant GST, N-terminus) (aa490-596) - LS-G60301

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human TCF7L2 / TCG4 Protein (Recombinant GST) (Full Length) - LS-G30648

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

75.79 kDa

Price:

2 µg/$439

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TCF7L2 / TCG4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101958

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.1 kDa

Price:

100 µg/$710

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Human TCF7L2 / TCG4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91971

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.5 kDa

Price:

20 µg/$150

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Human TCF7L2 / TCG4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91972

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.8 kDa

Price:

20 µg/$150

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Human TCF7L2 / TCG4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91973

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.2 kDa

Price:

20 µg/$150

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Human TCF7L2 / TCG4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91974

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.1 kDa

Price:

20 µg/$215

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Human TCF7L2 / TCG4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91967

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.9 kDa

Price:

20 µg/$150

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Human TCF7L2 / TCG4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91968

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.4 kDa

Price:

20 µg/$150

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Human TCF7L2 / TCG4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91970

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49 kDa

Price:

20 µg/$150

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TCF7L2 / TCG4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G130935

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

45.8 kDa

Price:

100 µg/$494

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TCF7L2 / TCG4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G130971

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.2 kDa

Price:

100 µg/$494

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TCF7L2 / TCG4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G130981

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.5 kDa

Price:

100 µg/$494

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TCF7L2 / TCG4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128266

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

65.9 kDa

Price:

100 µg/$494

Select

TCF7L2 / TCG4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128182

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.4 kDa

Price:

100 µg/$494

Select

TCF7L2 / TCG4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G128138

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49 kDa

Price:

100 µg/$494

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