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TFF3 / Trefoil Factor 3

trefoil factor 3 (intestinal)

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. TFF3 is expressed in goblet cells of the intestines and colon. The TFF3 gene consists of 3 exons, with exon 2 encoding the trefoil domain. The TFF1, TFF2, and TFF3 genes are located within a 55 kb region, suggesting they evolved from a common ancestor by duplication.

Gene Name: trefoil factor 3 (intestinal)
Synonyms: TFF3, HP1.B, Intestinal trefoil factor, HITF, ITF, TFI, p1B, Polypeptide P1.B, Trefoil factor 3, Trefoil factor 3 (intestinal)
Target Sequences: NM_003226

Publications (2)

1
Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression. Zhu Y, Zhao S, Deng Y, Gordillo R, Ghaben AL, Shao M, Zhang F, Xu P, Li Y, Cao H, Zagnitko O, Scott DA, Gupta RK, Xing C, Zhang BB, Lin HV, Scherer PE. Diabetes. 2017 November;66:2789-2799. [Full Text Article] [PubMed:28877911] [PMC:PMC5652600]
2
A reinforcing HNF4-SMAD4 feed-forward module stabilizes enterocyte identity. Lei Chen, Natalie H Toke, Shirley Luo, Roshan P Vasoya, Robert L Fullem, Aditya Parthasarathy, Ansu O Perekatt, Michael P Verzi. Nature genetics. 2019 May;51:777-785. [Full Text Article] [PubMed:30988513] [PMC:PMC6650150] Related Antibodies: LS-C662731.

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Products
Antibodies (101)
Primary (101)
TFF3 / Trefoil Factor 3 (101)
Human (34)
Mouse (21)
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rabbit (93)
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aa23-81 (32)
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TFF3 / Trefoil Factor 3 Antibody - Immunohistochemistry - Anti-TFF3/Itf Picoband antibody
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TFF3 / Trefoil Factor 3 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
TFF3 / Trefoil Factor 3 Antibody - Anti-TFF3 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Cancer Pathology
Cancer
TFF3 / Trefoil Factor 3 Mouse anti-Human Monoclonal (3D9) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$485
TFF3 / Trefoil Factor 3 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
TFF3 / Trefoil Factor 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
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TFF3 / Trefoil Factor 3 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$832
TFF3 / Trefoil Factor 3 Antibody - Immunohistochemistry of TFF3 in human small intestine tissue with TFF3 antibody at 2 µg/ml.
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TFF3 / Trefoil Factor 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, WB
Unconjugated
0.1 mg/$460
TFF3 / Trefoil Factor 3 Antibody - Immunohistochemistry - Anti-TFF3/Itf Picoband Antibody
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TFF3 / Trefoil Factor 3 Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
TFF3 / Trefoil Factor 3 Antibody - Western blot of recombinant TFF3 / Trefoil Factor 3.
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TFF3 / Trefoil Factor 3 Rabbit anti-Pig Polyclonal (aa22-80) Antibody
Pig
ICC, IP, WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
TFF3 / Trefoil Factor 3 Antibody - Western blot of recombinant TFF3 / Trefoil Factor 3.
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TFF3 / Trefoil Factor 3 Rabbit anti-Pig Polyclonal (aa22-80) (Biotin) Antibody
Pig
ICC, IP, WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
TFF3 / Trefoil Factor 3 Antibody - Western blot of recombinant TFF3 / Trefoil Factor 3.
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TFF3 / Trefoil Factor 3 Rabbit anti-Pig Polyclonal (aa22-80) (Cy3) Antibody
Pig
ICC, IP, WB
Cy3 Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
TFF3 / Trefoil Factor 3 Antibody - Western blot of recombinant TFF3 / Trefoil Factor 3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TFF3 / Trefoil Factor 3 Rabbit anti-Dog Polyclonal (aa24-80) Antibody
Dog
WB
Unconjugated
100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331
TFF3 / Trefoil Factor 3 Antibody - Western blot of recombinant TFF3 / Trefoil Factor 3.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TFF3 / Trefoil Factor 3 Rabbit anti-Dog Polyclonal (aa24-80) (Biotin) Antibody
Dog
WB
Biotin Conjugated
100 µl/$328; 200 µl/$378; 500 µl/$545; 1 ml/$645; 2 ml/$879; 5 ml/$1,464
TFF3 / Trefoil Factor 3 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TFF3 / Trefoil Factor 3 Rabbit anti-Human Polyclonal (aa22-94) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TFF3 / Trefoil Factor 3 Antibody - 1:100 staining mouse colon tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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TFF3 / Trefoil Factor 3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TFF3 / Trefoil Factor 3 Antibody - Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-TFF3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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TFF3 / Trefoil Factor 3 Mouse anti-Human Monoclonal (aa72-130) (OTI5B2) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
TFF3 / Trefoil Factor 3 Antibody - Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-TFF3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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TFF3 / Trefoil Factor 3 Mouse anti-Human Monoclonal (aa72-130) (Carrier-free) (OTI5B2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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TFF3 / Trefoil Factor 3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$351
TFF3 / Trefoil Factor 3 Antibody - Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-TFF3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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TFF3 / Trefoil Factor 3 Mouse anti-Human Monoclonal (aa72-130) (OTI4D10) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
TFF3 / Trefoil Factor 3 Antibody - Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-TFF3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:500)
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TFF3 / Trefoil Factor 3 Mouse anti-Human Monoclonal (aa72-130) (Carrier-free) (OTI4D10) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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TFF3 / Trefoil Factor 3 Mouse anti-Human Monoclonal (1D3G1) Antibody
Human
ELISA, IHC
Unconjugated
50 µg/$316; 100 µg/$386
TFF3 / Trefoil Factor 3 Antibody - Immunohistochemistry of paraffin-embedded Human colon cancer using TFF3 Polyclonal Antibody at dilution of 1:50.
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TFF3 / Trefoil Factor 3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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TFF3 / Trefoil Factor 3 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
Select
TFF3 / Trefoil Factor 3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$832
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TFF3 / Trefoil Factor 3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
Select
TFF3 / Trefoil Factor 3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
TFF3 / Trefoil Factor 3 Antibody - Immunodetection Analysis: Representative blot from a previous lot. Lane 1, recombinant protein Inhibin alpha. The membrane blot was probed with anti- Inhibin alpha primary antibody (0.2 µg/ml). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to IRDye 800CW detection system. Arrows indicate recombinant protein Inhibin alpha from E.coli cell (14kDa).
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TFF3 / Trefoil Factor 3 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).