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TGFB1 / TGF Beta 1

transforming growth factor, beta 1

TGFB1 / TGF Beta 1 is a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.

Gene Name:	transforming growth factor, beta 1
Family/Subfamily:	TGF beta , not assigned-TGF beta
Synonyms:	TGFB1, CED, DPD1, Diaphyseal dysplasia 1, LAP, Latency-associated peptide, TGF Beta, TGFbeta, TGF-beta 1 protein, TGF-beta-1, TGFB
Target Sequences:	NM_000660 NP_000651.3 P01137

Publications (13)

Blockade of KCa3.1 ameliorates renal fibrosis through the TGF-ß1/Smad pathway in diabetic mice. Huang C, Shen S, Ma Q, Chen J, Gill A, Pollock CA, Chen XM. Diabetes. 2013 62:2923-34. (WB; Zebrafish) [Full Text Article] [PubMed:23656889] [PMC:PMC3717839]

Bone regeneration in minipigs by intrafibrillarly-mineralized collagen loaded with autologous periodontal ligament stem cells. Zhang C, Yan B, Cui Z, Cui S, Zhang T, Wang X, Liu D, Yang R, Jiang N, Zhou Y, Liu Y. Scientific reports. 2017 September;7:10519. (Pig) [Full Text Article] [PubMed:28874877] [PMC:PMC5585269] Related Antibodies: LS-C10852.

Integrin a?ß5 in vitro inhibition limits pro-fibrotic response in cardiac fibroblasts of spontaneously hypertensive rats. Perrucci GL, Barbagallo VA, Corlianò M, Tosi D, Santoro R, Nigro P, Poggio P, Bulfamante G, Lombardi F, Pompilio G. Journal of translational medicine. 2018 December;16:352. [Full Text Article] [PubMed:30541573] [PMC:PMC6292173]

CD4+ primary T cells expressing HCV-core protein upregulate Foxp3 and IL-10, suppressing CD4 and CD8 T cells. Cecilia Fernandez-Ponce, Margarita Dominguez-Villar, Enrique Aguado, Francisco Garcia-Cozar. PloS one. 2014 January;9:e85191. [Full Text Article] [PubMed:24465502] [PMC:PMC3896374]

Obesity reduces mammary epithelial cell TGFß1 activity through macrophage-mediated extracellular matrix remodeling. Tamara Chamberlin, Victoria Thompson, Lauren E Hillers-Ziemer, Brenna N Walton, Lisa M Arendt. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 June;34:8611-8624. [Full Text Article] [PubMed:32359100] [PMC:PMC7317547] Related Antibodies: LS-B14345.

Pre- and Neonatal Exposure to Lead (Pb) Induces Neuroinflammation in the Forebrain Cortex, Hippocampus and Cerebellum of Rat Pups. Karina Chibowska, Jan Korbecki, Izabela Gutowska, Emilia Metryka, Maciej Tarnowski, Marta Goschorska, Katarzyna Barczak, Dariusz Chlubek, Irena Baranowska-Bosiacka. International journal of molecular sciences. 2020 February;21: [Full Text Article] [PubMed:32041252] [PMC:PMC7037720]

Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury. Wei-Zhong Ying, Xingsheng Li, Sunil Rangarajan, Wenguang Feng, Lisa M Curtis, Paul W Sanders. The Journal of clinical investigation. 2019 June;130:2792-2806. [Full Text Article] [PubMed:31205024] [PMC:PMC6597222]

Methylated Vnn1 at promoter regions induces asthma occurrence via the PI3K/Akt/NF?B-mediated inflammation in IUGR mice. Yan Xing, Hongling Wei, Xiumei Xiao, Zekun Chen, Hui Liu, Xiaomei Tong, Wei Zhou. Biology open. 2020 April;9: [Full Text Article] [PubMed:32139393] [PMC:PMC7197710]

Circulating TGF-ß1 as the potential epithelial mesenchymal transition-biomarker for diagnosis of cholangiocarcinoma. Phongsaran Kimawaha, Apinya Jusakul, Prem Junsawang, Watcharin Loilome, Narong Khuntikeo, Anchalee Techasen. Journal of gastrointestinal oncology. 2020 Apr;11:304-318. [Full Text Article] [PubMed:32399272] [PMC:PMC7212108] Related Antibodies: LS-C104537.

Histopathological and immunohistochemical evaluation of cellular response to a woven and electrospun polydioxanone (PDO) and polycaprolactone (PCL) patch for tendon repair. Mustafa Rashid, Jayesh Dudhia, Stephanie G Dakin, Sarah J B Snelling, Roberta De Godoy, Pierre-Alexis Mouthuy, Roger K W Smith, Mark Morrey, Andrew J Carr. Scientific reports. 2020 Mar;10:4754. [Full Text Article] [PubMed:32179829] [PMC:PMC7076042]

Methylated Vnn1 at promoter regions induces asthma occurrence via the PI3K/Akt/NF?B-mediated inflammation in the IUGR mice. Yan Xing, Hongling Wei, Xiumei Xiao, Zekun Chen, Hui Liu, Xiaomei Tong, Wei Zhou. Biology open. 2020 January;9: [Full Text Article] [PubMed:34004666]

Arrhythmogenic Hearts in PKD2 Mutant Mice Are Characterized by Cardiac Fibrosis, Systolic, and Diastolic Dysfunctions. Farideh Amirrad, Rajasekharreddy Pala, Kiumars Shamloo, Brian S Muntean, Surya M Nauli. Frontiers in cardiovascular medicine. 2021 December;8:772961. [Full Text Article] [PubMed:34901233] [PMC:PMC8661014]

Physiological Fluid Flow Moderates Fibroblast Responses to TGF-ß1. Sadhvi Nithiananthan, Aileen Crawford, Johnathan Cooper Knock, Daniel W Lambert, Simon A Whawell. Journal of cellular biochemistry. 2017 April;118:878-890. [Full Text Article] [PubMed:27748539] Related Antibodies: LS-C161825.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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