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TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

Gene Name: transforming growth factor, beta receptor II (70/80kDa)
Family/Subfamily: Protein Kinase , Activin/TGFb
Synonyms: TGFBR2, AAT3, FAA3, HNPCC6, LDS2B, MFS2, TGF-beta receptor type-2, TGF-beta RII, TGFBRII, TGF-beta type II receptor, TGFbeta-RII, TbetaR-II, TGF beta Receptor II, TGF-beta receptor type II, TGF-beta receptor type IIB, TGFR-2, LDS1B, RIIC, TAAD2
Target Sequences: NM_003242 NP_003233.4 P37173

☰ Filters
Antibodies (74)
ELISA Kits (18)
Proteins (18)
Cell-Based (1)
Custom (4)
Over-Expression Lysate (2)
Primary (74)
Recombinant (16)
Sandwich (13)
TGFBR2 (110)
Human (72)
Mouse (55)
Rat (21)
Bat (1)
Bovine (1)
Chicken (3)
Chimpanzee (3)
Gibbon (3)
Guinea pig (1)
Horse (1)
Monkey (5)
Pig (4)
Rabbit (3)
Sheep (1)
IHC (28)
IHC-P (7)
WB (57)
Flo (3)
ELISA (24)
ICC (5)
IF (12)
IP (1)
Peptide-ELISA (6)
SDS-PAGE (2)
rabbit (64)
mouse (4)
goat (4)
sheep (2)
Product Group
IHCPlus (1)
PathPlus Cancer (2)
IgG (46)
IgG1 (2)
IgG2a (2)
monoclonal mc (4)
polyclonal pc (70)
OTI3B4 (2)
OTI4F3 (2)
12 x 8-Well Microstrips (1)
96-Well Microplate (3)
96-Well Strip Plate (14)
APC (1)
APC Conjugated (4)
Azide-free (2)
Biotin Conjugated (6)
Carrier-free (2)
CF Conjugated (1)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (3)
PerCP Conjugated (1)
Unconjugated (47)
aa209-590 (8)
aa13-40 (7)
aa548-575 (7)
N-Terminus (4)
aa23-294 (4)
Extracellular Domain (3)
Internal (2)
pSer225 (2)
160-240 aa (1)
60-140 aa, Internal (1)
Glu246 (1)
aa100-150 (1)
aa191-240 (1)
aa25-159 (1)
aa27-85 (1)
aa330-346 (1)
aa475-525 (1)
aa517-567 (1)
aa73-122 (1)
aa77-148 (1)
aa91-140 (1)
aa96-128 (1)
p250 (1)
pSer225/250 (1)
pSer225/Ser250 (1)
No (110)
Adherent Cell Cultures (1)
Cell Culture Supernatants (3)
Cell Lysates (3)
Cell Supernatant (1)
Plasma (11)
Serum (11)
Tissue Homogenates (7)
10His, N-terminus + Myc, C-terminus (1)
6His, C-terminus (2)
Fc (1)
Fc, C-terminus (5)
GST (1)
GST, N-terminus (2)
His (1)
His,C-terminus (1)
Human IgG Fc, C-terminus (1)
Myc-DDK (Flag) (3)
Human (8)
Mouse (6)
Rat (3)
293T Cells (1)
Baculovirus (2)
E. coli (1)
HEK 293 Cells (3)
Human (1)
Human Cells (4)
Mammalian Cells (3)
Wheat Germ Extract (3)
Purified (3)
Low endotoxin level (10)
TGFBR2 Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
TGFBR2 Rabbit anti-Human Polyclonal (aa13-40) Antibody
Mouse, Human
IF, IHC-P, WB
Unconjugated
200 µl/$460
Select
TGFBR2 Goat anti-Mouse Polyclonal (APC) Antibody
Mouse
Flo
APC Conjugated
100 Tests/$896
TGFBR2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
TGFBR2 Rabbit anti-Human Polyclonal (aa517-567) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TGFBR2 Antibody - Immunohistochemical analysis of TGFBR2 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected with HRP and DAB as chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
TGFBR2 Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Mouse, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
42.3kD
10 µg/$266; 50 µg/$343; 500 µg/$1,377; 1 mg/$1,765
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.2kD
10 µg/$266; 50 µg/$343; 500 µg/$1,869; 1 mg/$2,991
Select
TGFBR2 Goat anti-Mouse Polyclonal (Extracellular Domain) (PerCP) Antibody
Mouse
Flo
PerCP Conjugated
100 Tests/$859
TGFBR2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Baculovirus
10His, N-terminus + Myc, C-terminus
100 µg/$810; 20 µg/$387; 1 mg/$1,678
TGFBR2 Antibody - Immunohistochemistry of paraffin-embedded human brain tissue using TGFBR2 Antibody at dilution of 1:100
Select
TGFBR2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
Select
TGFBR2 Rabbit anti-Human Polyclonal (aa25-159) (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
TGFBR2 Rabbit anti-Human Polyclonal (aa13-40) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
Select
TGFBR2 Rabbit anti-Mouse Polyclonal (aa13-40) (FITC) Antibody
Mouse
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
Select
TGFBR2 Rabbit anti-Mouse Polyclonal (aa13-40) (PE) Antibody
Mouse
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
Select
TGFBR2 Rabbit anti-Mouse Polyclonal (aa13-40) (APC) Antibody
Mouse
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
TGFBR2 Antibody - Western blot of p-TGFBR2 (S225/250) antibody at 1:500 dilution. Lane 1: HEK293T cell lysate treated with EGF(0.1ng/ml,30mins). Lane 2: Raw264.7 cell lysate treated with EGF(0.1ng/ml,30mins). Lane 3: H9C2 cell lysate treated with EGF(0.1ng/ml,30mins).
Select
TGFBR2 Rabbit anti-Human Polyclonal (pSer225) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$431
TGFBR2 Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using TGFBR2 antibody at dilution of 1:100 (40x lens).
Select
TGFBR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
TGFBR2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$748
TGFBR2 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-TGFBR2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:2000)
Select
TGFBR2 Mouse anti-Human Monoclonal (aa23-294) (OTI3B4) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
TGFBR2 Antibody - IHC of TGF RII (E246) pAb in paraffin-embedded human brain tissue.
Select
TGFBR2 Rabbit anti-Human Polyclonal (Glu246) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
Select
TGFBR2 Rabbit anti-Mouse Polyclonal (aa548-575) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
Select
TGFBR2 Rabbit anti-Human Polyclonal (aa475-525) Antibody
Human
IP
Unconjugated
10 µg/$295; 100 µl/$514
Select
Baculovirus
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human TGFBR2 consists of 154 amino acids and predicts a molecular mass of 17.7 kDa.
100 µg/$441; 1 mg/$2,003
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
16.2 kDa
10 µg/$266; 50 µg/$339
TGFBR2 Antibody - Western blot of TGFbeta RII antibody
Select
TGFBR2 Rabbit anti-Human Polyclonal (60-140 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TGFBR2 Antibody - Western blot analysis of lysates from HepG2 (65K) cells, using TGF beta Receptor II Antibody. The lane on the right is blocked with the synthesized peptide.
Select
TGFBR2 Rabbit anti-Human Polyclonal (aa91-140) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Viewing 1-25 of 110 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).