TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.

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Products

ELISA Kits (18)

Type

Cell-Based (1)

Custom (4)

Sandwich (13)

Target

TGFBR2 (18)

Reactivity

Human (10)

Mouse (3)

Rat (4)

Chicken (1)

Pig (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (3)

96-Well Strip Plate (14)

Publications

No (18)

Sample Type

Adherent Cell Cultures (1)

Cell Culture Supernatants (3)

Cell Lysates (3)

Cell Supernatant (1)

Plasma (11)

Serum (11)

Tissue Homogenates (7)

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Mouse TGFBR2 (Sandwich ELISA) ELISA Kit - LS-F8659

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$748

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Human TGFBR2 (Sandwich ELISA) ELISA Kit - LS-F3393

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

2.048 - 500 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$534

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Human TGFBR2 (Sandwich ELISA) ELISA Kit - LS-F6708

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$730

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Mouse/Human TGFBR2 (Cell-Based ELISA) ELISA Kit - LS-F2348

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Human TGFBR2 (Sandwich ELISA) ELISA Kit - LS-F2967

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$699

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Human TGFBR2 (Sandwich ELISA) ELISA Kit - LS-F1007

Type:

Sandwich

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

16 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum

Price:

1 Plate/$534

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Human TGFBR2 (Sandwich ELISA) ELISA Kit - LS-F12747

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Rat TGFBR2 (Sandwich ELISA) ELISA Kit - LS-F32181

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

78.125 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Rat TGFBR2 (Sandwich ELISA) ELISA Kit - LS-F39021

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$783

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Human TGFBR2 (Sandwich ELISA) ELISA Kit - LS-F31474

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum

Price:

1 Plate/$624

Select

Human TGFBR2 (Sandwich ELISA) ELISA Kit - LS-F33413

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human TGFBR2 (Sandwich ELISA) ELISA Kit - LS-F38235

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$586

Select

Human TGFBR2 (Sandwich ELISA) ELISA Kit - LS-F54844

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

15.6 - 1000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$897

Select

Rat TGFBR2 (Sandwich ELISA) ELISA Kit - LS-F75065

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Supernatant, Plasma, Serum

Price:

1 Plate/$598

Select

Pig TGFBR2 (Custom ELISA) ELISA Kit - LS-F20612

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Rat TGFBR2 (Custom ELISA) ELISA Kit - LS-F20613

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Mouse TGFBR2 (Custom ELISA) ELISA Kit - LS-F20614

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Chicken TGFBR2 (Custom ELISA) ELISA Kit - LS-F20615

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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