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TNFRSF14 / CD270 / HVEM

tumor necrosis factor receptor superfamily, member 14

HVEM (Herpes virus entry mediator) is a member of the tumor necrosis factor receptor family. This family of receptors plays a central role in the development of the immune system. HVEM has been shown to mediate HSV entry into activated T cells, in addition to modulating the activation of nuclear factor NF-kB (a transcriptional activator of multiple immuno modulatory and inflammatory genes) and transcription factor AP-1 (a regulator of cellular stress-response genes). Binding by HVEM of the ligand LIGHT induces receptor down regulation. Degradation or release of LIGHT by matrix metalloproteinases then contributes to the return to baseline levels for both LIGHT and HVEM. Soluble HVEM, which tends to form disulfide-linked heterodimeric complexes in solution, can act as a “receptor decoy” resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-beta.

Gene Name: tumor necrosis factor receptor superfamily, member 14
Family/Subfamily: TNF Receptor , not assigned-TNF Receptor
Synonyms: TNFRSF14, CD270, CD270 antigen, CD40-like protein, Herpesvirus entry mediator, Herpesvirus entry mediator A, HVEM, LIGHTR, Herpes virus entry mediator A, TR2, ATAR, HVEA
Target Sequences: NM_003820 NP_003811.2 Q92956

Publications (3)

1
Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailability. Cheung TC, Coppieters K, Sanjo H, Oborne LM, Norris PS, Coddington A, Granger SW, Elewaut D, Ware CF. Journal of immunology (Baltimore, Md. : 1950). 2010 185:1949-58. [PubMed:20592286] [PMC:PMC2921593] Related Antibodies: LS-C41150.
2
B and T lymphocyte attenuator mediates inhibition of tumor-reactive CD8+ T cells in patients after allogeneic stem cell transplantation. Hobo W, Norde WJ, Schaap N, Fredrix H, Maas F, Schellens K, Falkenburg JH, Korman AJ, Olive D, van der Voort R, Dolstra H. Journal of immunology (Baltimore, Md. : 1950). 2012 189:39-49. [PubMed:22634623] Related Antibodies: LS-C41150.
3
Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer. Ramsay AG, Clear AJ, Fatah R, Gribben JG. Blood. 2012 120:1412-21. (WB; Human) [Full Text Article] [PubMed:22547582] [PMC:PMC3423779] Related Antibodies: LS-C41150.

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ELISA Kits (8)
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TNFRSF14 / CD270 / HVEM (8)
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TNFRSF14 / CD270 / HVEM ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
TNFRSF14 / CD270 / HVEM ELISA Kit
Select
Sandwich
96-Well Microplate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
TNFRSF14 / CD270 / HVEM ELISA Kit
Select
Sandwich
96-Well Microplate
Human
32.77 - 3200 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$760
TNFRSF14 / CD270 / HVEM ELISA Kit
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Sandwich
Human
15.6 - 1000 pg/ml
Cell Culture Supernatants, Cell Lysates, EDTA Plasma, Heparin Plasma, Serum
1 Plate/$699
TNFRSF14 / CD270 / HVEM ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
TNFRSF14 / CD270 / HVEM ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
TNFRSF14 / CD270 / HVEM ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
TNFRSF14 / CD270 / HVEM ELISA Kit
Select
Competitive EIA
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).