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TRPA1
transient receptor potential cation channel, subfamily A, member 1
Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.
| Gene Name: | transient receptor potential cation channel, subfamily A, member 1 |
| Family/Subfamily: | Ion Channel , Calcium channel - TRP |
| Synonyms: | TRPA1, ANKTM1, TRPA-1 |
| Target Sequences: | NM_007332 CAA71610.1 O75762 |
Publications (8)
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