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Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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TTR / Transthyretin
transthyretin
TTR / Transthyretin is transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
| Gene Name: | transthyretin |
| Synonyms: | TTR, ATTR, CTS1, CTS, HsT2651, PALB, Prealbumin, TBPA, Transthyretin, Carpal tunnel syndrome 1, Prealbumin, amyloidosis type I, Thyroxine-binding prealbumin |
| Target Sequences: | NM_000371 NP_000362.1 P02766 |
Publications (4)
1
Gene expression and functional annotation of human choroid plexus epithelium failure in Alzheimer's disease. Bergen AA, Kaing S, ten Brink JB; Netherlands Brain Bank, Gorgels TG, Janssen SF. BMC genomics. 2015 16:956. (IHC; Human)
[Full Text Article]
[PubMed:26573292]
[PMC:PMC4647590]
2
A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing. Finn JD, Smith AR, Patel MC, Shaw L, Youniss MR, van Heteren J, Dirstine T, Ciullo C, Lescarbeau R, Seitzer J, Shah RR, Shah A, Ling D, Growe J, Pink M, Rohde E, Wood KM, Salomon WE, Harrington WF, Dombrowski C, Strapps WR, Chang Y, Morrissey DV. Cell reports. 2018 February;22:2227-2235. [Full Text Article]
[PubMed:29490262]
Related Antibodies: LS-C407961.
3
Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies. Michaela Auer-Grumbach, Stefan Toegel, Maria Schabhüttl, Daniela Weinmann, Catharina Chiari, David L H Bennett, Christian Beetz, Dennis Klein, Peter M Andersen, Ilka Böhme, Regina Fink-Puches, Michael Gonzalez, Matthew B Harms, William Motley, Mary M Reilly, Wilfried Renner, Sabine Rudnik-Schöneborn, Beate Schlotter-Weigel, Andreas C Themistocleous, Jochen H Weishaupt, Albert C Ludolph, Thomas Wieland, Feifei Tao, Lisa Abreu, Reinhard Windhager, Manuela Zitzelsberger, Tim M Strom, Thomas Walther. American journal of human genetics. 2016 September;99:607-623. [Full Text Article]
[PubMed:27588448]
[PMC:PMC5011077]
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Proteins
(35)
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Over-Expression Lysate
(2)
Recombinant
(33)
Target
TTR / Transthyretin
(35)
Application
Bind
(1)
ELISA
(1)
Func
(1)
SDS-PAGE
(3)
Publications
No
(34)
Yes
(1)
Tag
6His, C-terminus
(2)
6His, N-terminus
(5)
6His-SUMO, N-terminus
(2)
GST
(1)
GST, N-terminus
(1)
His
(8)
His, N-Terminal
(3)
His,C-terminus
(2)
His,N-terminus
(1)
His-SUMO
(1)
His-T7
(3)
Myc-DDK (Flag)
(3)
Species
Bovine
(1)
Chicken
(1)
Crab-eating macaque
(1)
Cynomolgus monkey
(1)
Dog
(1)
Guinea pig
(1)
Human
(16)
Mouse
(7)
Orangutan
(1)
Pig
(1)
Rabbit
(1)
Rat
(1)
Zebrafish
(1)
Source
293T Cells
(1)
E. coli
(23)
HEK 293 Cells
(5)
Human Cells
(2)
Mammalian Cells
(2)
Wheat Germ Extract
(1)
Yeast
(1)
Purification
Purified
(9)
Low Endotoxin Level
Low endotoxin level
(7)
Biologically Active
Biologically active
(1)
E. coli
His
15.8 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
6His, N-terminus
17.8 kD
100 µg/$598; 20 µg/$405; 1 mg/$1,679
E. coli
None
100 µg/$342; 500 µg/$641; 20 µg/$254
E. coli
His
15.2 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
His, N-Terminal
17.4 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
His-T7
16.4 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
E. coli
His-T7
17.4 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
HEK 293 Cells
Myc-DDK (Flag)
13.7 kDa
20 µg/$1,107
E. coli
His
15.7 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
His
15 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
His
15.3 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
E. coli
His-T7
17.8 kDa
50 µg/$500; 10 µg/$290; 200 µg/$997; 100 µg/$797; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329
E. coli
His
17.9 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
E. coli
His-SUMO
29.5 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
Wheat Germ Extract
GST
39.71 kDa
10 µg/$479; 25 µg/$670
HEK 293 Cells
His,C-terminus
Bind ELISA Func SDS-PAGE
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
The secreted recombinant human TTR comprises 138 amino acids with a predicted molecular mass of 15.2 kDa.
100 µg/$441; 1 mg/$2,003
293T Cells
Myc-DDK (Flag)
15.89 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
15.89 kDa
100 µg/$494
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
15.2 kDa
100 µg/$721
E. coli
His, N-Terminal
13.3kDa
10 µg/$271; 50 µg/$382; 200 µg/$762; 100 µg/$610; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$3,041
HEK 293 Cells
His,N-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant human TTR consists of 142 amino acids and predicts a molecular mass of 15.7 kDa.
100 µg/$480
HEK 293 Cells
His,C-terminus
SDS-PAGE
Less than 1.0 EU/µg protein (determined by LAL method).
The recombinant mouse TTR consists of 127 amino acids and predicts a molecular mass of 13.6 kDa.
100 µg/$480
E. coli
His, N-Terminal
15.9
50 µg/$419
E. coli
6His, N-terminus
18.3 kDa
1 mg/$1,679; 100 µg/$500; 20 µg/$364
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