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UMOD / Uromodulin

uromodulin

UMOD / Uromodulin is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.

Gene Name: uromodulin
Synonyms: UMOD, ADMCKD2, FJHN, HNFJ, MCKD2, THGP, THP, Uromucoid, Tamm-Horsfall glycoprotein, HNFJ1, Uromodulin
Target Sequences: NM_003361 NP_003352.2 P07911

Publications (6)

1
Extracellular vesicles in urine of women with but not without kidney stones manifest patterns similar to men: a case control study. Jayachandran M, Lugo G, Heiling H, Miller VM, Rule AD, Lieske JC. Biology of sex differences. 2015 6:2. (Flo; Human) [Full Text Article] [PubMed:25729563] [PMC:PMC4345020] Related Antibodies: LS-B3105.
2
Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys. Turco AE, Lam W, Rule AD, Denic A, Lieske JC, Miller VM, Larson JJ, Kremers WK, Jayachandran M. Journal of Extracellular Vesicles. 2016 5:29642. (Flo; Human) [PubMed:26837814] [PMC:PMC4737715] Related Antibodies: LS-B3105.
3
Novel fixed z-direction (FiZD) kidney primordia and an organoid culture system for time-lapse confocal imaging. Saarela U, Akram SU, Desgrange A, Rak-Raszewska A, Shan J, Cereghini S, Ronkainen VP, Heikkilä J, Skovorodkin I, Vainio SJ. Development (Cambridge, England). 2017 144:1113-1117. (IHC; Mouse) [Full Text Article] [PubMed:28219945] [PMC:PMC5358112]
4
Urinary extracellular vesicle-associated MCP-1 and NGAL derived from specific nephron segments differ between calcium oxalate stone formers and controls. Robin S Chirackal, Muthuvel Jayachandran, Xiangling Wang, Samuel Edeh, Zejfa Haskic, Majuran Perinpam, Timothy M Halling, Ramila Mehta, Marcelino E Rivera, John C Lieske. American journal of physiology. Renal physiology. 2019 December;317:F1475-F1482. [Full Text Article] [PubMed:31461349] [PMC:PMC6962507] Related Antibodies: LS-B3105.
5
Mouse Embryonic Stem Cell-Derived Ureteric Bud Progenitors Induce Nephrogenesis. Zenglai Tan, Aleksandra Rak-Raszewska, Ilya Skovorodkin, Seppo J Vainio. Cells. 2020 Jan;9:329. [Full Text Article] [PubMed:32023845] [PMC:PMC7072223]
6
Healthy Women Have Higher Systemic Uromodulin Levels: Identification of Uromodulin as an Estrogen Responsive Gene. Azuma Nanamatsu, Radmila Micanovic, Shehnaz Khan, Tarek M El-Achkar, Kaice A LaFavers. Kidney360. 2023 September;4:e1302-e1307. [Full Text Article] [PubMed:37340540] [PMC:PMC10475773]
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UMOD / Uromodulin (97)
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UMOD / Uromodulin Antibody - Anti-UMOD / Uromodulin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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UMOD / Uromodulin Mouse anti-Human Monoclonal (FITC) (10.32) Antibody
Dog, Human
ELISA, IF, IHC, IHC-Fr, IHC-P
FITC Conjugated
50 µg/$460
UMOD / Uromodulin Antibody - Anti-UMOD / Uromodulin antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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Cancer
UMOD / Uromodulin Mouse anti-Human Monoclonal (10.32) Antibody
Dog, Human
IF, IHC, IHC-Fr, IHC-P
Unconjugated
50 µg/$460
UMOD / Uromodulin Antibody - Anti-UMOD / Uromodulin antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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UMOD / Uromodulin Rabbit anti-Human Polyclonal (aa352-380) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
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UMOD / Uromodulin Mouse anti-Human Monoclonal (10.32) Antibody
Human
IF, IHC, IHC-Fr, IHC-P
Unconjugated
1 ml/$503
UMOD / Uromodulin Antibody - Western blot of recombinant UMOD / Uromodulin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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UMOD / Uromodulin Rabbit anti-Rat Polyclonal (aa30-150) Antibody
Rat
WB
Unconjugated
100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$783
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$748
UMOD / Uromodulin Protein
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Yeast
6His, N-terminus
64.22 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
UMOD / Uromodulin Antibody - UMOD / Uromodulin antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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UMOD / Uromodulin Rabbit anti-Human Polyclonal (aa503-552) Antibody
Human
WB
Unconjugated
100 µl/$424
UMOD / Uromodulin Antibody - UMOD / Uromodulin antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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UMOD / Uromodulin Rabbit anti-Human Polyclonal (aa503-552) (Biotin) Antibody
Dog, Guinea pig, Bovine, Horse, Human, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
UMOD / Uromodulin Antibody - Anti-UMOD / Uromodulin antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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Cancer
UMOD / Uromodulin Rabbit anti-Human Polyclonal (Val378) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
UMOD / Uromodulin Protein - Purified recombinant protein UMOD was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
67.1 kDa
20 µg/$1,107
UMOD / Uromodulin Protein - Recombinant  Uromodulin By SDS-PAGE
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E. coli
His,N-terminus
29.8 kDa
10 µg/$283; 50 µg/$452; 200 µg/$905; 1 mg/$2,020; 5 mg/$3,165; 2 mg/$2,209
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UMOD / Uromodulin Mouse anti-Human Monoclonal (HRP) (10.32) Antibody
Human
IF, IHC, IHC-Fr, IHC-P
HRP Conjugated
100 µg/$466
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UMOD / Uromodulin Rabbit anti-Human Polyclonal (aa352-380) (Azide-free) (HRP) Antibody
Human
IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
UMOD / Uromodulin Protein - Recombinant Uromodulin By SDS-PAGE
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E. coli
His-GST
60.8 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
UMOD / Uromodulin Antibody - 1:100 staining mouse kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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UMOD / Uromodulin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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UMOD / Uromodulin Sheep anti-Mouse Polyclonal (aa24-618) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$930
UMOD / Uromodulin Antibody - UMOD / Uromodulin antibody Western blot of THP-1 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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UMOD / Uromodulin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
UMOD / Uromodulin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
UMOD / Uromodulin Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$460
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UMOD / Uromodulin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
UMOD / Uromodulin Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
UMOD / Uromodulin Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
60 µl/$460
UMOD / Uromodulin ELISA Kit
Select
Sandwich
96-Well Microplate
Human
40.96 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$760
UMOD / Uromodulin Protein - Recombinant Uromodulin By SDS-PAGE
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E. coli
His-T7
16.5 kDa
10 µg/$286; 50 µg/$472; 100 µg/$757; 200 µg/$945; 1 mg/$2,073; 500 µg/$1,604; 5 mg/$3,305; 2 mg/$2,262
UMOD / Uromodulin ELISA Kit
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Sandwich
96-Well Strip Plate
Dog
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Viewing 1-25 of 97 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).