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UMOD / Uromodulin

uromodulin

UMOD / Uromodulin is the most abundant protein in mammalian urine under physiological conditions. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. This protein may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of this protein in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the renal disorders medullary cystic kidney disease-2 (MCKD2), glomerulocystic kidney disease with hyperuricemia and isosthenuria (GCKDHI), and familial juvenile hyperuricemic nephropathy (FJHN). Alternative splicing of this gene results in multiple transcript variants.

Gene Name: uromodulin
Synonyms: UMOD, ADMCKD2, FJHN, HNFJ, MCKD2, THGP, THP, Uromucoid, Tamm-Horsfall glycoprotein, HNFJ1, Uromodulin
Target Sequences: NM_003361 NP_003352.2 P07911

Publications (6)

1
Extracellular vesicles in urine of women with but not without kidney stones manifest patterns similar to men: a case control study. Jayachandran M, Lugo G, Heiling H, Miller VM, Rule AD, Lieske JC. Biology of sex differences. 2015 6:2. (Flo; Human) [Full Text Article] [PubMed:25729563] [PMC:PMC4345020] Related Antibodies: LS-B3105.
2
Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys. Turco AE, Lam W, Rule AD, Denic A, Lieske JC, Miller VM, Larson JJ, Kremers WK, Jayachandran M. Journal of Extracellular Vesicles. 2016 5:29642. (Flo; Human) [PubMed:26837814] [PMC:PMC4737715] Related Antibodies: LS-B3105.
3
Novel fixed z-direction (FiZD) kidney primordia and an organoid culture system for time-lapse confocal imaging. Saarela U, Akram SU, Desgrange A, Rak-Raszewska A, Shan J, Cereghini S, Ronkainen VP, Heikkilä J, Skovorodkin I, Vainio SJ. Development (Cambridge, England). 2017 144:1113-1117. (IHC; Mouse) [Full Text Article] [PubMed:28219945] [PMC:PMC5358112]
4
Urinary extracellular vesicle-associated MCP-1 and NGAL derived from specific nephron segments differ between calcium oxalate stone formers and controls. Robin S Chirackal, Muthuvel Jayachandran, Xiangling Wang, Samuel Edeh, Zejfa Haskic, Majuran Perinpam, Timothy M Halling, Ramila Mehta, Marcelino E Rivera, John C Lieske. American journal of physiology. Renal physiology. 2019 December;317:F1475-F1482. [Full Text Article] [PubMed:31461349] [PMC:PMC6962507] Related Antibodies: LS-B3105.
5
Mouse Embryonic Stem Cell-Derived Ureteric Bud Progenitors Induce Nephrogenesis. Zenglai Tan, Aleksandra Rak-Raszewska, Ilya Skovorodkin, Seppo J Vainio. Cells. 2020 Jan;9:329. [Full Text Article] [PubMed:32023845] [PMC:PMC7072223]
6
Healthy Women Have Higher Systemic Uromodulin Levels: Identification of Uromodulin as an Estrogen Responsive Gene. Azuma Nanamatsu, Radmila Micanovic, Shehnaz Khan, Tarek M El-Achkar, Kaice A LaFavers. Kidney360. 2023 September;4:e1302-e1307. [Full Text Article] [PubMed:37340540] [PMC:PMC10475773]
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Products
Proteins (13)
Over-Expression Lysate (4)
Recombinant (9)
UMOD / Uromodulin (13)
No (13)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
His (2)
His,N-terminus (1)
His-GST (1)
His-T7 (1)
Myc-DDK (Flag) (5)
Dog (1)
Human (6)
Mouse (2)
Rat (2)
293T Cells (2)
E. coli (5)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Yeast (1)
Purified (1)
Low endotoxin level (1)
UMOD / Uromodulin Protein
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Yeast
6His, N-terminus
64.22 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
UMOD / Uromodulin Protein - Purified recombinant protein UMOD was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
67.1 kDa
20 µg/$1,107
UMOD / Uromodulin Protein - Recombinant  Uromodulin By SDS-PAGE
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E. coli
His,N-terminus
29.8 kDa
10 µg/$283; 50 µg/$452; 200 µg/$905; 1 mg/$2,020; 5 mg/$3,165; 2 mg/$2,209
UMOD / Uromodulin Protein - Recombinant Uromodulin By SDS-PAGE
Select
E. coli
His-GST
60.8 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
UMOD / Uromodulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
69.76 kDa
20 µg/$215
UMOD / Uromodulin Protein - Recombinant Uromodulin By SDS-PAGE
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E. coli
His-T7
16.5 kDa
10 µg/$286; 50 µg/$472; 100 µg/$757; 200 µg/$945; 1 mg/$2,073; 500 µg/$1,604; 5 mg/$3,305; 2 mg/$2,262
UMOD / Uromodulin Protein - 12.5% SDS-PAGE of human UMOD stained with Coomassie Blue
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Wheat Germ Extract
GST
93.1 kDa
10 µg/$479; 25 µg/$670
UMOD / Uromodulin Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
293T Cells
Myc-DDK (Flag)
69.76 kDa
20 µg/$215
UMOD / Uromodulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
69.76 kDa
100 µg/$710
Select
HEK 293 Cells
Myc-DDK (Flag)
69.76 kDa
100 µg/$710
Select
E. coli
121 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
13.42 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
UMOD / Uromodulin Protein - Recombinant Uromodulin By SDS-PAGE
Select
E. coli
His
13.8 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).