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WT1 / Wilms Tumor 1
Wilms tumor 1
WT1 / Wilms Tumor 1 is a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
| Gene Name: | Wilms tumor 1 |
| Synonyms: | WT1, GUD, EWS-WT1, Amino-terminal domain of EWS, WAGR, WIT-2, Wilms tumor protein, AWT1, Wilms tumor 1, WT33, NPHS4, WT-1 |
| Target Sequences: | NM_024426 NP_077744.3 P19544 |
Publications (5)
1
Characterization of monoclonal antibodies directed to the amino-terminus of the WT1, Wilms' tumor suppressor protein. Rauscher FJ, Morris JF, Fredericks WJ, Lopez-Guisa J, Balakrishnan C, Jost M, Herlyn M, Rodeck U. Hybridoma. 1998 17:191-8.
[PubMed:9627060]
2
WT1 protein directly regulates expression of vascular endothelial growth factor and is a mediator of tumor response to hypoxia. McCarty G, Awad O, Loeb DM. The Journal of biological chemistry. 2011 286:43634-43.
[PubMed:22030397]
[PMC:PMC3243556]
3
Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip. Musah S, , Mammoto A, Ferrante TC, Jeanty SSF, Hirano-Kobayashi M, Mammoto T, Roberts K, Chung S, Novak R, Ingram M, Fatanat-Didar T, Koshy S, Weaver JC, Church GM, , Ingber DE, ,. Nature biomedical engineering. 2017 1: (IHC; Human)
[Full Text Article]
[PubMed:29038743]
Related Antibodies: LS-C224662.
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WT1 / Wilms Tumor 1
(112)
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(111)
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(1)
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Cancer
WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (1E9) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$485
WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (aa396-448) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Mouse, Human
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Mouse, Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (aa346-375) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (Concentrated) (6F-H2) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated, Concentrated
1 ml/$840
WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (N-Terminus) (6F-H2) Antibody
Human
IHC, IHC-P
Unconjugated
0.1 ml/$284; 0.5 ml/$500; 1 ml/$735
E. coli
6His-SUMO, N-terminus
65.2 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Sandwich
96-Well Strip Plate
Human
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
HEK 293 Cells
6His, N-terminus
36.8 kDa
100 µg/$298
WT1 / Wilms Tumor 1 Rabbit anti-Human Monoclonal (RMWT1-1) Antibody
Human
IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
WT1 / Wilms Tumor 1 Rabbit anti-Human Monoclonal (Azide-free, BSA-free) (RMWT1-1) Antibody
Human
IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (aa346-375) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200 µl/$734
WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (aa346-375) (Biotin) Antibody
Human
ELISA, Flo, IF, IHC, WB
Biotin Conjugated
200 µl/$952
WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (aa346-375) (FITC) Antibody
Human
ELISA, Flo, IF, IHC, WB
FITC Conjugated
200 µl/$952
WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (aa346-375) (APC) Antibody
Human
FLISA, IF, IHC, WB
APC Conjugated
200 µl/$952
WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (aa346-375) (PE) Antibody
Human
ELISA, IF, IHC, WB
PE Conjugated
200 µl/$952
WT1 / Wilms Tumor 1 Rabbit anti-Human Polyclonal (aa346-375) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (Ready-to-Use) (WT1/857) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (aa1-181) (6F-H2) Antibody
Human
IHC, IP, WB
Unconjugated
0.1 ml/$386
WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (aa1-181) (Biotin) (6F-H2) Antibody
Human
IHC, IP, WB
Biotin Conjugated
0.1 ml/$416
WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (aa1-181) (DY488) (6F-H2) Antibody
Human
IHC, IP, WB
DY488 Conjugated
0.1 ml/$416
WT1 / Wilms Tumor 1 Mouse anti-Human Monoclonal (aa1-181) (DY650) (6F-H2) Antibody
Human
IHC, IP, WB
DY650 Conjugated
0.1 ml/$416
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