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Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
Gene Name: | WW domain containing oxidoreductase |
Synonyms: | WWOX, D16S432E, FRA16D, FOR, HHCMA56, PRO0128, SDR41C1, WOX1 |
Target Sequences: | NM_016373 NP_057457.1 Q9NZC7 |
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